Prenatal Stress Produces Social Behavior Deficits and Alters the Number of Oxytocin and Vasopressin Neurons in Adult Rats
Prenatal Stress Produces Social Behavior Deficits and Alters the Number of Oxytocin and Vasopressin Neurons in Adult Rats
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DOI：
10.1007/s11064-013-1049-5
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发表时间：
2013-07-01
影响因子：
4.4
通讯作者：
Lucion, Aldo Bolten
中科院分区：
文献类型：
--
作者：
de Souza, Marcelo Alves;Centenaro, Ligia Aline;Lucion, Aldo Bolten
本研究调查了产前反复束缚应激对社会行为和焦虑的长期影响，及其对成年期应激幼崽的室旁核（PVN）和视上核（SON）的催产素（OT）和加压素（VP）阳性神经元的影响。雌性 Wistar 大鼠在怀孕最后 7 天受到束缚压力。出生时，幼崽被交叉抚养并分配到以下组：由产前无应激母亲抚养的产前无应激后代（NS：NS），由产前应激母亲抚养的产前无应激后代（S：NS），由产前无应激母亲抚养的产前应激后代（NS：S），产前应激 由产前压力过大的母亲抚养的后代 (S:S)。成年后，由有压力的母亲（S:S 组）和无压力的母亲（NS:S 组）抚养长大的男性产前压力后代表现出社会记忆和互动受损。此外，当两种不利条件共存时（S:S组），观察到焦虑样行为和攻击性增加与PVN的OT阳性大细胞神经元、VP阳性大细胞和小细胞神经元数量减少相关。与 S:NS 组相比，NS:S 组表现出 VP 阳性大细胞神经元数量减少。因此，在 S:S 和 NS:S 组中观察到的社会行为缺陷可能仅部分与肽能系统的这些改变相关。 SON 核的 OT 和 VP 细胞组成没有变化。尽管如此，显然应特别注意妊娠期，因为这段时期的压力事件可能与成年期行为障碍的出现有关。
The present study investigated the long-lasting effects of prenatal repeated restraint stress on social behavior and anxiety, as well as its repercussions on oxytocin (OT) and vasopressin (VP)-positive neurons of the paraventricular (PVN) and supraoptic (SON) nuclei from stressed pups in adulthood. Female Wistar rats were exposed to restraint stress in the last 7 days of pregnancy. At birth, pups were cross-fostered and assigned to the following groups: prenatally non-stressed offspring raised by prenatally non-stressed mothers (NS:NS), prenatally non-stressed offspring raised by prenatally stressed mothers (S:NS), prenatally stressed offspring raised by prenatally non-stressed mothers (NS:S), prenatally stressed offspring raised by prenatally stressed mothers (S:S). As adults, male prenatally stressed offspring raised both by stressed mothers (S:S group) and non-stressed ones (NS:S group) showed impaired social memory and interaction. In addition, when both adverse conditions coexisted (S:S group), increased anxiety-like behavior and aggressiveness was observed in association with a decrease in the number of OT-positive magnocellular neurons, VP-positive magnocellular and parvocellular neurons of the PVN. The NS:S group exhibited a reduction in the amount of VP-positive magnocellular neurons compared to the S:NS. Thus, the social behavior deficits observed in the S:S and NS:S groups may be only partially associated with these alterations to the peptidergic systems. No changes were shown in the OT and VP cellular composition of the SON nucleus. Nevertheless, it is clear that a special attention should be given to the gestational period, since stressful events during this time may be related to the emergence of behavioral impairments in adulthood.