Wound-Healing Properties of Copper Nanoparticles as a Function of Physicochemical Parameters
Wound-Healing Properties of Copper Nanoparticles as a Function of Physicochemical Parameters
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DOI：
10.1134/s199507801003016x
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发表时间：
2010-04-01
影响因子：
0.8
通讯作者：
Glushchenko, N. N.
中科院分区：
文献类型：
--
作者：
Rakhmetova, A. A.;Alekseeva, T. P.;Glushchenko, N. N.
本文报道了高温缩合制备的铜纳米粒子的伤口愈合潜力和物理化学特性的研究结果，并与各种药剂（包括氧气、水蒸气和空气）修饰。在监测条件下对铜纳米颗粒进行改性，保证了不同尺寸、相组成、厚度和氧化层组成的颗粒种类的合成。以软膏形式修饰的铜纳米颗粒显示出不同的伤口愈合行为，其效果取决于其物理化学参数。氧化铜纳米粒子（样品7）（空气修饰）的粒径为119 nm，结晶铜含量约为0.5%；铜纳米粒子（样品2）（氧修饰）的粒径为103 nm，结晶铜含量为96%，表现出最大的伤口粘附率。
Results of a study on the wound-healing potential and physicochemical characteristics of copper nanoparticles prepared by high-temperature condensation and modified with a variety of agents (including oxygen, water vapors, and air) are reported. The modification of copper nanoparticles under monitored conditions guarantees the synthesis of particle species differing in size, phase composition, thickness, and composition of the oxide layer. Modified copper nanoparticles in the form of an ointment showed wound-healing behavior that differs in effectiveness depending on their physicochemical parameters. Nanoparticles of copper oxide (sample 7) (modified with air), with a particle size of 119 nm and crystalline copper content of similar to 0.5%, and copper nanoparticles (sample 2) (modified with oxygen), with a particle size of 103 nm and crystalline copper content of 96%, demonstrated the maximum specific rate of wound adhesion.