DIFFERENTIATED CARDIOVASCULAR AFFERENT REGULATION OF LOCUS COERULEUS NEURONS AND SYMPATHETIC-NERVES
DIFFERENTIATED CARDIOVASCULAR AFFERENT REGULATION OF LOCUS COERULEUS NEURONS AND SYMPATHETIC-NERVES
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DOI：
10.1016/0006-8993(85)90950-3
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发表时间：
1985-01-01
期刊：
影响因子：
2.9
通讯作者：
THOREN, P
中科院分区：
文献类型：
--
作者：
ELAM, M;SVENSSON, TH;THOREN, P
在动脉血压和循环血容量变化过程中，同步记录蓝斑（LC）脑内去甲肾上腺素（NE）神经元的活动和内脏/肾神经的外周交感神经活动（NE-SNA）。利用这个实验程序，我们以前发现，中枢和外周NE神经元在血压升高过程中受到抑制。此外，这两个神经元系统被发现在血容量负荷，迷走神经传入介导的效果明显抑制。在本研究中，脑NE-LC活性和NE-SNA在血容量减少时增加。然而，在长期出血期间，NE-SNA的初始兴奋之后是明显的抑制。相反，NE-LC活性的增加在整个血容量耗竭期间保持不变。双侧颈迷走神经切断后，出血时中枢和外周NE神经元的反应消失。硝普钠或苯肾上腺素引起的血压变化与中枢和外周NE神经元活动的相互变化有关。双侧迷走神经切断术后，NE-LC对血压变化的反应消失。另一方面，双侧迷走神经切断术后，NE-SNA反应持续存在。我们目前和以前的研究结果表明，大脑NE LC神经元，类似于外周NE神经元的内脏/肾神经，调节紧张性活动的心血管传入。虽然外周NE-SNA受动脉（高压）压力感受器和心脏容量（低压）受体的调节，但NE-LC神经元似乎仅受心脏容量（低压）受体的调节。
The activity of brain norepinephrine (NE) neurons in the locus coeruleus (LC) and peripheral sympathetic nerve activity (NE-SNA) in the splanchnic/renal nerve were recorded simultaneously during alterations of arterial blood pressure and circulating blood volume. Utilizing this experimental procedure we have previously found that both central and peripheral NE neurons are inhibited during blood pressure elevation. Furthermore, both neuronal systems were found to be inhibited during blood volume load, an effect apparently mediated by vagal afferents. In the present study both brain NE-LC activity and NE-SNA were increased during blood volume depletion. However, during prolonged hemorrhage the initial excitation of NE-SNA was followed by a marked inhibition. In contrast, the increase in NE-LC activity remained throughout the volume depletion period. The responses of central and peripheral NE neurons during hemorrhage were abolished in animals subjected to bilateral cervical vagotomy. Nitroprusside- or phenylephrine-induced blood pressure variations were associated with reciprocal changes in both central and peripheral NE neuronal activity. The NE-LC responses to blood pressure variations were abolished after bilateral vagotomy. NE-SNA responses, on the other hand, persisted after bilateral vagotomy. Our present and previous findings show that brain NE-LC neurons, similarly to peripheral NE neurons in the splanchnic/renal nerve, are regulated by tonically active cardiovascular afferents. Whereas peripheral NE-SNA is regulated by both arterial (high pressure) baroreceptors and cardiac volume (low pressure) receptors, the NE-LC neurons seem exclusively regulated by cardiac volume (low pressure) receptors.