The relationship of primary tumor thickness in carcinoma of the tongue to subsequent lymph node metastasis
The relationship of primary tumor thickness in carcinoma of the tongue to subsequent lymph node metastasis
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DOI：
10.1038/sj.dmfr.4600615
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发表时间：
2001-09-01
影响因子：
3.3
通讯作者：
Katsura, K
中科院分区：
文献类型：
--
作者：
Hayashi, T;Ito, J;Katsura, K
目的：研究I/II期舌癌原发灶厚度是否为后续淋巴结转移提供信息。方法：对20例T1N0M0或T2N0M0舌癌患者进行研究。用增强后螺旋CT或口腔内超声测量原发肿瘤厚度。每隔2~4周定期进行颈淋巴结超声检查。结果：在随访期内，9例患者的9个结节超声检查均为阳性。11名患者接受了颈淋巴清扫术，9名患者有组织病理学阳性的淋巴结。9名患者在至少20个月的随访期内没有发现转移的超声检查结果。原发肿瘤厚度3~16 mm。以5 mm为界，判断舌癌转移的敏感度、特异度和准确度分别为10 0%、10 0%和75%。结论：厚度大于5 mm的I/II期舌癌患者更易发生淋巴结转移。
Objectives: To study whether primary tumor thickness of stage I/II tongue carcinoma provides information about subsequent lymph node metastasis.Methods: Twenty consecutive patients with T1N0M0 or T2N0M0 tongue carcinoma were studied. Primary tumor thickness was measured with post-contrast helical computed tomography or intra-oral sonography. Cervical lymph nodes were evaluated periodically with sonography at intervals of 2-4 weeks. Sensitivity, specificity and accuracy for subsequent metastasis was calculated.Results: Positive sonographic findings appeared in nine nodes of nine patients during this follow-up period. Eleven patients underwent neck dissections, and nine had histopathologically positive nodes. Nine patients had no sonographic findings of metastasis during a minimum follow-up period of 20 months. Primary tumor thickness varied from 3 - 16 mm. Using 5 mm as a cut-off thickness, the sensitivity, specificity and accuracy for subsequent lymph node metastasis were 64, 100 and 75% respectively.Conclusions: Patients with stage I/II tongue carcinoma which is more than 5 mm thick are more likely to develop lymph node metastasis.