A quantitative trait locus for body fat on chromosome 1q43 in French Canadians: Linkage and association studies
A quantitative trait locus for body fat on chromosome 1q43 in French Canadians: Linkage and association studies
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DOI：
10.1038/oby.2006.185
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发表时间：
2006-09-01
期刊：
影响因子：
6.9
通讯作者：
Bouchard, Claude
中科院分区：
文献类型：
--
作者：
Aissani, Brahim;Perusse, Louis;Bouchard, Claude
目的：在魁北克家系研究队列中探索影响体重指数、肥胖和非脂肪体重表型的人类染色体1Q上的数量性状基因座。研究方法和步骤：利用密集的染色体1q43微卫星和单核苷酸多态标记，对885名成年个体进行非参数同胞对和方差成分连锁分析和基于家族的关联分析。结果：标记D1S184与体重指数(p=0.0004)和体脂质量或体重之间存在连锁。体脂百分比(p
Objective: To explore a quantitative trait locus (QTL) on human chromosome 1q affecting BMI, adiposity, and fat-free mass phenotypes in the Quebec Family Study cohort.Research Methods and Procedures: Non-parametric sibpair and variance component linkage analyses and family-based association studies were performed with a dense set of chromosome 1q43 microsatellites and single-nucleotide polymorphism markers in 885 adult individuals.Results: Linkage was observed between marker D1S184 and BMI (p = 0.0004) and with body fat mass or. percentage body fat (p