Parsing Brain Activity Associated with Acupuncture Treatment in Parkinson's Diseases
Parsing Brain Activity Associated with Acupuncture Treatment in Parkinson's Diseases
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DOI：
10.1002/mds.22673
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发表时间：
2009-09-15
影响因子：
8.6
通讯作者：
Park, Hi-Joon
中科院分区：
文献类型：
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作者：
Chae, Younbyoung;Lee, Hyejung;Park, Hi-Joon
针灸是补充和替代医学中的一种常见治疗方式，已广泛用于治疗帕金森病 (PD)。利用功能磁共振成像（fMRI），我们探讨了具体而真实的针灸治疗对帕金森病患者运动功能影响的神经机制。以区块设计随机顺序对 10 名 PD 患者左脚运动功能相关穴位 GB34 进行 3 次 fMRI 扫描，一次用于精针 (VA) 治疗，另一次用于隐性安慰剂 (CP) 治疗，第三次用于显性安慰剂 (OP) 治疗。我们计算了减去针灸效应（VA 与 CP）和安慰剂效应（CP 与 OP）的血氧水平依赖性 (BOLD) 反应的对比度。我们发现针灸治疗后患手的运动功能显着改善。当 PD 患者接受针灸治疗（VA 与 CP）时，壳核和初级运动皮层被激活，这些激活与个体运动功能的增强相关。对针灸方式（CP 与 OP）的期望引发了前扣带回、额上回和颞上回的激活。这些发现表明，针灸治疗可能通过基底神经节-丘脑皮质回路促进帕金森病患者的运动功能改善。 (C) 2009 运动障碍协会
Acupuncture, a common treatment modality within complementary and alternative medicine, has been widely used for Parkinson's disease (PD). Using functional magnetic resonance imaging (fMRI), we explored the neural mechanisms underlying the effect of specific and genuine acupuncture treatment on the motor function in patients with PD. Three fMRI scans were performed in random order in a block design, one for verum acupuncture (VA) treatment, another one for a covert placebo (CP), and the third one for an overt placebo (OP) at the motor function implicated acupoint GB34 on the left foot of 10 patients with PD. We calculated the contrast that subtracts the blood-oxygen-level dependent (BOLD) response for the acupuncture effect (VA vs. CP) and the placebo effect (CP vs. OP). We found a signiticant improvement in the motor function of the affected hand after acupuncture treatment. The putamen and the primary motor cortex were activated when patients with PD received the acupuncture treatment (VA vs. CP) and these activations correlated with individual enhanced motor function. Expectation towards acupuncture modality (CP vs. OP) elicited activation over the anterior cingulate gyrus, the superior frontal gyrus, and the superior temporal gyrus. These findings suggest that acupuncture treatment might facilitate improvement in the motor functioning of patients with PD via the basal ganglia-thalamocortical circuit. (C) 2009 Movement Disorder Society