Reduced all-cause mortality with antipsychotics and antidepressants compared to increased all-cause mortality with benzodiazepines in patients with schizophrenia observed in naturalistic treatment settings
Reduced all-cause mortality with antipsychotics and antidepressants compared to increased all-cause mortality with benzodiazepines in patients with schizophrenia observed in naturalistic treatment settings
复制标题
在自然治疗环境中观察到的精神分裂症患者中，与苯二氮卓类药物增加的全因死亡率相比，抗精神病药物和抗抑郁药物的全因死亡率降低
DOI：
10.1136/eb-2016-102525
复制
发表时间：
2017
影响因子：
5.2
通讯作者：
Christoph U Corell
中科院分区：
文献类型：
--
作者：
J. Rubio;Christoph U Corell
摘要：Tiihonen J， Mittendorfer-Rutz E， Torniainen M等。精神分裂症患者的死亡率和抗精神病药、抗抑郁药和苯二氮卓类药物的累积暴露：一项观察性随访研究[J]中华精神病学杂志，2016;33 (3):391 - 391
ABSTRACT FROM: Tiihonen J, Mittendorfer-Rutz E, Torniainen M et al. Mortality and cumulative exposure to antipsychotics, antidepressants, and benzodiazepines in patients with schizophrenia: an observational follow-up study. Am J Psychiatry 2016;173:600–6.[OpenUrl][1]
Individuals with schizophrenia die ∼15–20 years prematurely compared to the general population, mostly due to cardiovascular disease, obesity-related cancer, diabetes and chronic obstructive pulmonary disease.1 Owing to the known metabolic effects of antipsychotics,2 clarifying their role in increased mortality is important. Paradoxically, prior studies in schizophrenia have suggested a relative decrement in mortality with moderate antipsychotic doses compared to no antipsychotic exposure. Cohort studies have indicated an elevated mortality risk with benzodiazepines in several populations, but adjustment for other treatment variables has been limited.
A cohort of 21 492 individuals aged 17–65 years old who lived in Sweden in 2005 and who received treatment for schizophrenia prior to the beginning of 2006 was followed for 5 years. This cohort was derived from nationwide registers representing all contacts with healthcare in Sweden during the study period. The cumulative prescription of antipsychotics, benzodiazepines and …
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