Specific bronchoalveolar lavage IgA antibody in patients with summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum.
Specific bronchoalveolar lavage IgA antibody in patients with summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum.
复制标题
皮肤毛孢子菌所致夏季型过敏性肺炎患者支气管肺泡灌洗液特异性IgA抗体
DOI：
10.1164/arrd.1986.134.1.177
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Araki
中科院分区：
文献类型：
--
作者：
M. Ando;K. Yoshida;K. Soda;S. Araki
本文对皮肤毛孢子菌引起的夏季型过敏性肺炎患者血清中抗毛孢子菌特异性IgG、伊加和分泌型伊加（S-IgA）抗体进行了研究。血清和支气管肺泡灌洗液（BALF）中的皮肤。一株T.从1例患者的枕头上分离出皮肤。该家系所有成员（2例患者和2例无症状者）的血清均含有抗T IgG抗体。患者与无症状家庭成员之间的滴度无差异。另一方面，血清和BALF中伊加和S-IgA抗体活性仅在患者中显著升高，且滴度与临床病程密切相关。BALF/血清中特异性抗体活性的比值在伊加和S-IgA抗体活性中显著升高，与IgG中的活性形成鲜明对比，提示呼吸道的免疫反应。T.皮肤抗原阳性的患者，但没有在无症状的家庭成员。提示血清和BALF中伊加和S-IgA抗体活性的测定对诊断和评价夏季型过敏性肺炎的病情活动性有重要意义。
Patients with summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum were studied with respect to specific IgG, IgA, and secretory IgA (S-IgA) antibody activities to T. cutaneum in serum and bronchoalveolar lavage fluid (BALF). A strain of T. cutaneum was isolated from 1 patient's pillow. All serum samples from the family members (2 patients and 2 asymptomatic) contained IgG antibody activity to T. cutaneum, and the titers showed no difference between the patients and asymptomatic family members. On the other hand, IgA and S-IgA antibody activities in serum and BALF were markedly increased only in the patients, and the titers were well correlated with the clinical course. The BALF/serum ratio of specific antibody activity was markedly elevated in IgA and S-IgA antibody activities in striking contrast to that in IgG, suggesting an immune reaction of the respiratory tract. The bronchial challenge test with T. cutaneum antigen was positive in the patients, but not in an asymptomatic family member. These results indicate that measurement of IgA and S-IgA antibody activities in serum and BALF is useful for diagnosis and evaluation of disease activity in summer-type hypersensitivity pneumonitis.