A case study of primary progressive aphasia: Improvement on verbs after rTMS treatment
A case study of primary progressive aphasia: Improvement on verbs after rTMS treatment
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DOI：
10.1080/13554790601126203
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发表时间：
2006-12-01
期刊：
影响因子：
0.8
通讯作者：
Fierro, Brigida
中科院分区：
文献类型：
--
作者：
Finocchiaro, Chiara;Maimone, Mario;Fierro, Brigida
该病例报告表明，应用于左前额叶皮质的高频重复经颅磁刺激（hf-rTMS）可以改善原发性进行性失语症（PPA）的语言技能。在两次hf-rTMS治疗和一次SHAM治疗前后，对患者的语言产生和记忆广度任务进行了评估。我们观察到，与基线和SHAM条件相比，应用hf-rTMS后，患者的动词产生表现得到了显着且持久的改善。这一发现表明，hf-rTMS可以直接加强代谢功能障碍区域内的神经连接，并鼓励使用rTMS作为神经退行性失语症的替代治疗工具。
This case-report shows that high frequency repetitive Transcranial Magnetic Stimulation (hf-rTMS), applied to the left prefrontal cortex, may improve the linguistic skills in Primary Progressive Aphasia (PPA). The patient's performance was evaluated on a battery of language production and memory span tasks, before and after two hf-rTMS treatments and one SHAM treatment. We observed a significant and lasting improvement of the patient's performance on verb production following the application of hf-rTMS versus Baseline and SHAM conditions. This finding suggests that hf-rTMS may directly strengthen the neural connections within an area of metabolic dysfunction and encourages the use of rTMS as an alternative therapeutic tool for neurodegenerative forms of aphasia.