A new cytosine glycoside from Streptomyces griseochromogenes produced by the use in vivo of enzyme inhibitors.
A new cytosine glycoside from Streptomyces griseochromogenes produced by the use in vivo of enzyme inhibitors.
复制标题
一种来自灰产色链霉菌的新型胞嘧啶糖苷，通过体内使用酶抑制剂产生。
DOI：
10.1021/np970468o
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Zabriskie,TM
中科院分区：
文献类型：
--
作者：
Zhang,Q;Gould,SJ;Zabriskie,TM
采用体内酶抑制法研究了抗真菌抗生素杀稻瘟菌素S（1）生物合成途径中新的胞嘧啶糖苷和中间体的鉴定。研究发现，添加精氨酸类似物精氨酸或精氨酸琥珀酸合成酶抑制剂2-甲基天冬氨酸的灰产色链霉菌（Streptomycesgriseochromogenes）发酵可产生一种新的代谢产物（7）。
The identification of new cytosine glycosides and intermediates in the biosynthetic pathway of the antifungal antibiotic blasticidin S (1) was investigated using in vivo enzyme inhibition. Fermentations ofStreptomyces griseochromogenes, the organism that produces1, supplemented with the arginine analogue argininic acid or the argininosuccinate synthase inhibitor 2-methylaspartic acid were found to produce a new metabolite (7).