The influence of resin chemistry on a dental composite's biodegradation
The influence of resin chemistry on a dental composite's biodegradation
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DOI：
10.1002/jbm.a.30000
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发表时间：
2004-05-01
影响因子：
4.9
通讯作者：
Santerre, JP
中科院分区：
文献类型：
--
作者：
Finer, Y;Santerre, JP
先前的工作报道，商业牙科复合树脂含有一个双修饰的bisGMA（双苯基缩水甘油基二甲基丙烯酸酯）/TEGDMA（三甘醇二甲基丙烯酸酯）（ubis）为基础的单体系统显示了一个10倍的减少释放的bisGMA衍生的产品，双羟基丙氧基苯基丙烷（bisHPPP）相比，发现bisGMA/TEGDMA（双）为基础的复合材料与胆固醇酯酶（CE）孵育后。不幸的是，这些材料在填料类型和含量方面也有很大差异，因此不可能将任何具体参数与生物降解水平的差异直接联系起来。通过控制填料的含量和类型，目前的研究将试图探索复合树脂化学和酯酶活性之间的生物分子相互作用，以帮助解释ubis和bis树脂系统之间生物降解水平的差异。孵育32天后，使用高效液相色谱法、紫外光谱法和质谱法分析缓冲液和CE溶液中的降解产物。这两种材料，其特征在于通过傅里叶变换红外光谱，扫描电子显微镜，和X射线光电子能谱。在CE组中，ubis系统显示出相对于bis系统分离产物的量减少2.6- 86倍（取决于产物）（p < 0.01）。扫描电子显微镜的数据也证明了ubis系统的相对稳定性和X-射线光电子能谱分析表明，在表面的双样品的酯键的含量较高。傅立叶变换红外数据表明，两种树脂具有相似的转化率。由于两种系统除单体系统外均相同，因此得出结论，生物稳定性变化与化学相关。交联、疏水性和溶解性都与ubis的前稳定性有关。(C)2004 Wiley Periodicals，Inc.
Previous work reported that commercial dental composite resins containing a urethane-modified bisGMA (bisphenylglycidyl dimethacrylate)/TEGDMA (triethylene glycol dimethacrylate) (ubis) based monomer system showed a 10-fold reduction in the release of a bisGMA-derived product, bishydroxypropoxyphenyl propane (bisHPPP), as compared with that found for bisGMA/TEGDMA (bis) based composites after incubation with cholesterol esterase (CE). Unfortunately, these materials also differed substantially in filler type and content, making it impossible to directly relate any specific parameter to the differences in biodegradation levels. By controlling for filler content and type, the current study will seek to probe the biomolecular interactions between composite resin chemistry and esterase activity in order to help explain the observed differences in biodegradation levels between the ubis and bis resin systems. After 32 days of incubation, buffer and CE solutions were analyzed for degradation products using high-performance liquid chromatography, UV spectroscopy, and mass spectrometry. Both materials were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. In the CE groups, the ubis system showed a 2.6- to 86-fold reduction (dependent on the product) in the amount of isolated products relative to the bis system (p < 0.01). Scanning electron microscopy data also demonstrated the relative stability of the ubis system and X-ray photoelectron spectroscopy analysis showed a higher content of the ester bond at the surface of the bis samples. Fourier transform infrared data showed that both resins had similar conversions. Because both systems were identical except for their monomer systems, it was concluded that changes in biostability were associated with chemistry. Crosslinking, hydrophobicity, and solubility all relate to ubis's pro-stability. (C) 2004 Wiley Periodicals, Inc.