Pituitary apoplexy: do histological features influence the clinical presentation and outcome?
Pituitary apoplexy: do histological features influence the clinical presentation and outcome?
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DOI：
10.3171/jns.2006.104.6.931
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发表时间：
2006-06-01
影响因子：
4.1
通讯作者：
Laws, Edward R., Jr.
中科院分区：
文献类型：
--
作者：
Semple, Patrick L.;De Villiers, Jacques C.;Laws, Edward R., Jr.
Object.回顾性分析一组同期垂体卒中患者，以确定组织病理学特征是否影响临床表现或预后。对在弗吉尼亚州夏洛茨维尔的弗吉尼亚大学卫生系统或南非开普敦大学Groote Schuur医院接受垂体卒中治疗的59例患者进行了回顾性分析。根据其疾病的组织学特征将患者分为两组：一组为单纯梗死，包括22例患者;另一组为出血性梗死和/或明显出血，包括37例患者。比较两组患者的临床症状、临床特征、内分泌状况及预后。仅表现为垂体瘤梗死的组织学特征的患者，与表现为出血性梗死或明显出血的患者相比，其临床表现较轻，病程较长，预后较好。两组的内分泌替代需求相似。
Object. A retrospective analysis of a contemporary series of patients with pituitary apoplexy was performed to ascertain whether the histopathological features influence the clinical presentation or the outcome.Methods. A retrospective analysis was performed in 59 patients treated for pituitary apoplexy at the University of Virginia Health System, Charlottesville, Virginia, or Groote Schuur Hospital, University of Cape Town, South Africa. The patients were divided into two groups according to the histological features of their disease: one group with infarction alone, comprising 22 patients; and the other with hemorrhagic infarction and/or frank hemorrhage, comprising 37 patients. The presenting symptoms, clinical features, endocrinological status, and outcome were compared between the two groups.Conclusions. The patients who presented with histological features of pituitary tumor infarction alone had less severe clinical features on presentation, a longer course prior to presentation, and a better outcome than those presenting with hemorrhagic infarction or frank hemorrhage. The endocrine replacement requirements were similar in both groups.