The heritability of otitis media - A twin and triplet study
The heritability of otitis media - A twin and triplet study
复制标题
DOI：
10.1001/jama.282.22.2125
复制
发表时间：
1999-12-08
影响因子：
120.7
通讯作者：
Ferrell, RE
中科院分区：
文献类型：
--
作者：
Casselbrant, ML;Mandel, EM;Ferrell, RE
背景解剖学，生理学，目的探讨儿童中耳积液和急性中耳炎（AOM）的发病时间和发病次数的遗传因素，为临床治疗提供依据。设计前瞻性双胞胎和三胞胎队列研究，从1982年到1995年招募。设置中耳炎研究中心，在耳，鼻，在出生后的前2个月内，总共招募了168个健康的同性双胞胎和7个三胞胎组;可获得140组的合子型结果;随访1年者138例（99%），随访2年者126例（90%）。主要指标按合子状态统计中耳积液时间、中耳积液发作次数和AOM发作次数的比例。中耳积液时间的遗传度为0.73（P <0.001）。3次或3次以上中耳积液的不一致性估计值在单卵双胞胎中为0.04，在双卵双胞胎中为0.37（P = 0.01）。单卵双胞胎AOM发作的不一致性估计为0.04，而双卵双胞胎为0.49（P = 0.005）。结论我们的研究表明，儿童中耳积液和AOM发作的时间量有很强的遗传成分。
Context Anatomical, physiological, and epidemiological data indicate that there may be a significant genetic component to prolonged time with and recurrent episodes of otitis media in children.Objective To determine the genetic component of time with and episodes of middle ear effusion and acute otitis media (AOM) during the first 2 years of life.Design Prospective twin and triplet cohort study with enrollment from 1982 through 1995.Setting Otitis Media Research Center in the ear, nose, and throat clinic of Children's Hospital of Pittsburgh, Pittsburgh, Pa.Patients A total of 168 healthy same-sex twin and 7 triplet sets were recruited within the first 2 months of life; zygosity results were available for 140 sets; 138 (99%) of these were followed up for 1 year and 126 (90%) for 2 years.Main Outcome Measures Proportion of time with middle ear effusion, episodes of middle ear effusion, and episodes of AOM by zygosity status,Results At the 2-year end point, the estimate of heritability of time with middle ear effusion was 0.73 (P < .001). The estimates of discordance for 3 or more episodes of middle ear effusion were 0.04 for monozygotic twins and 0.37 for dizygotic twins (P = .01). The estimate of discordance of an episode of AOM in monozygotic twins was 0.04 compared with 0.49 in dizygotic twins (P = .005).Conclusions Our study suggests there is a strong genetic component to the amount of time with middle ear effusion and episodes of middle ear effusion and AOM in children.