The aging bladder insights from animal models.
The aging bladder insights from animal models.
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DOI：
10.1016/j.ajur.2017.03.004
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发表时间：
2018-07
影响因子：
2.6
通讯作者：
Chapple CR
中科院分区：
文献类型：
--
作者：
Birder LA;Kullmann AF;Chapple CR
随着年龄的增长，膀胱功能的改变非常常见，并且随着人口的普遍老龄化，在未来几年中很可能代表日益严重的医疗保健问题。在这篇综述中，作者描述了下尿路症状（LUTS）的患病率，并根据实验室研究对可能导致下尿路症状患病率随年龄增长而增加的潜在机制进行了评论。很明显，膀胱的神经支配结构的各种成分之间存在复杂的相互作用，导致随着年龄的变化，这可能是在老化膀胱中看到的LUTS的基础。
Alterations in bladder function with aging are very common and are very likely to represent an increasing healthcare problem in the years to come with the general aging of the population. In this review the authors describe the prevalence of lower urinary tract symptoms (LUTS) and comment upon potential mechanisms which may be responsible for the increasing prevalence of lower LUTS with increasing age, based on laboratory studies. It is clear that there is a complex interplay between the various components of the neural innervation structure of the bladder in leading to changes with age, which are likely to underpin the LUTS which are seen in the aging bladder.