A model experiment to understand the oral phase of swallowing of Newtonian liquids
A model experiment to understand the oral phase of swallowing of Newtonian liquids
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DOI：
10.1016/j.jbiomech.2015.09.022
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发表时间：
2015-11-05
影响因子：
2.4
通讯作者：
Ramaioli, M.
中科院分区：
文献类型：
--
作者：
Hayoun, P.;Engmann, J.;Ramaioli, M.
一个模型实验，以了解吞咽的口腔阶段，并用来解释一些控制牛顿液体吞咽的机制。定量研究了通过增加液体的粘度或体积而使流动减慢的程度。用于吞咽的力的效果和用于表示收缩的舌头的腭和辊之间的差距也被量化。当增加差距时，模型吞咽后留下的液体的残留质量强烈上升，并且与推注体积和施加的力无关。过高的粘度导致较高的残留物，除了成功地减慢推注流之外。一个现实的理论开发和用于解释的实验观察，突出存在的初始瞬态制度，在恒定的加速度，可以遵循一个稳定的粘性制度，在恒定的速度。当恒定加速度方案主导团流时，液体粘度对总口服通过时间的影响较低。我们的理论还表明，舌头惯性是在以前的研究中观察到的舌后部较高的压力的原因，本研究中提出的方法为人类吞咽的机械模型铺平了道路，这将有助于设计新颖的，物理上健全的，吞咽困难的治疗方法及其在体内评估和临床试验之前的初步筛选。(C)2015爱思唯尔有限公司版权所有。
A model experiment to understand the oral phase of swallowing is presented and used to explain some of the mechanisms controlling the swallowing of Newtonian liquids. The extent to which the flow is slowed down by increasing the viscosity of the liquid or the volume is quantitatively studied. The effect of the force used to swallow and of the gap between the palate and the roller used to represent the contracted tongue are also quantified. The residual mass of liquid left after the model swallow rises strongly when increasing the gap and is independent of bolus volume and applied force. An excessively high viscosity results in higher residues, besides succeeding in slowing down the bolus flow. A realistic theory is developed and used to interpret the experimental observations, highlighting the existence of an initial transient regime, at constant acceleration, that can be followed by a steady viscous regime, at constant velocity. The effect of the liquid viscosity on the total oral transit time is lower when the constant acceleration regime dominates bolus flow. Our theory suggests also that tongue inertia is the cause of the higher pressure observed at the back of the tongue in previous studies.The approach presented in this study paves the way toward a mechanical model of human swallowing that would facilitate the design of novel, physically sound, dysphagia treatments and their preliminary screening before in vivo evaluations and clinical trials. (C) 2015 Elsevier Ltd. All rights reserved.