Relative proteolysis of the fibrinogen Bβ chain by thrombin and plasmin as a determinant of thrombosis
Relative proteolysis of the fibrinogen Bβ chain by thrombin and plasmin as a determinant of thrombosis
复制标题
凝血酶和纤溶酶对纤维蛋白原 Bβ 链的相对蛋白水解作为血栓形成的决定因素
作者：
H. Nossel
血栓形成的部分原因是纤维蛋白的局部积聚，这意味着其形成速度和溶解速度之间存在不平衡。Astrup1假设血管系统的通畅依赖于持续活跃的凝血和纤溶系统之间的动态平衡。对这一假说的回顾得出的结论是，凝血酶和纤溶酶蛋白分解都不会对正常人的纤维蛋白原周转起主要作用2，凝血和溶解之间存在动态平衡的假说仍未得到证实。因此，目前的观点认为，纤溶酶只是起到在血管系统中消化纤维蛋白的纤溶酶的作用。在这里，我提出了另一种观点，即凝血酶和纤溶酶对纤维蛋白原Bβ链的相对蛋白水解率决定了血栓的发生。这一观点得到了最新数据的支持，可以用来做出一些容易检验的预测。
Thrombosis results, in part, from localized accumulation of fibrin, implying an imbalance between its rate of formation and dissolution. Astrup1 postulated that patency of the vascular system depended on a dynamic equilibrium between constantly active coagulation and fibrinolytic systems. Reviews of this hypothesis have concluded that neither thrombin nor plasmin proteolysis makes a major contribution to fibrinogen turnover in normal individuals2 and that the hypothesis of a dynamic equilibrium between clotting and lysis remains unproven3. Thus, the current view is that plasmin simply serves the function of a fibrinolytic enzyme digesting fibrin in the vascular system. Here, I promote the alternative view that the relative rates of proteolysis of the Bβ chain of fibrinogen by thrombin and plasmin determine the occurrence of thrombosis. This view is supported by recent data and can be used to make some readily testable predictions.