Functional cholesteryl binding agents: synthesis, characterization, and evaluation of antibody binding to modified phospholipid vesicles.
Functional cholesteryl binding agents: synthesis, characterization, and evaluation of antibody binding to modified phospholipid vesicles.
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功能性胆固醇结合剂：与修饰磷脂囊泡结合的抗体的合成、表征和评估。
DOI：
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发表时间：
1986
影响因子：
7.3
通讯作者：
A. G. Jones
中科院分区：
文献类型：
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作者：
T. Carroll;A. Davison;A. G. Jones
合成了一系列功能化胆固醇衍生物。分析了各种亲脂性蛋白修饰剂的蛋白结合能力。确定了125I标记的人IgG与修饰磷脂囊泡的结合。两种药剂表现良好。分别为胆-5-en-3 -酰基5-羧基戊基醚琥珀酰亚胺酯和胆-5-en-3 -酰基6-羧基己基醚琥珀酰亚胺酯。
A series of functionalized cholesteryl derivatives were synthesized. The various lipophilic protein modification agents were analyzed for their protein binding ability. The binding of human IgG, labeled with 125I, to modified phospholipid vesicles was ascertained. Two agents performed well. These were cholest-5-en-3 beta-yl 5-carboxypentyl ether succinimido ester and cholest-5-en-3 beta-yl 6-carboxyhexyl ether succinimido ester.