Catalytic Enantioselective Trifluoromethylation of Azomethine Imines with Trimethyl(trifluoromethyl)silane
Catalytic Enantioselective Trifluoromethylation of Azomethine Imines with Trimethyl(trifluoromethyl)silane
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DOI：
10.1002/anie.200902457
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Shibata, Norio
中科院分区：
文献类型：
--
作者：
Kawai, Hiroyuki;Kusuda, Akihiro;Shibata, Norio
这是轻而易举的事！标题反应与亚甲亚胺1使用操作简单的程序，基于金鸡纳生物碱(3)的溴化物盐和KOH的组合。该程序是可靠和通用的。三氟甲基取代胺可通过对产物(S)-2进行两步脱保护得到。
It's a cinch! The title reaction with azomethine imines 1 uses an operationally simple procedure, based on the combination of the bromide salt of cinchona alkaloids (3) and KOH. The procedure is reliable and general. Trifluoromethyl-substituted amines can be accessed by a two-step deprotection of the product (S)-2.