Rapamycin: Brain excitability studied in vitro
Rapamycin: Brain excitability studied in vitro
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DOI：
10.1111/j.1528-1167.2006.00976.x
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发表时间：
2007-04-01
期刊：
影响因子：
5.6
通讯作者：
Gorji, Ali
中科院分区：
文献类型：
--
作者：
Daoud, Delchad;Scheld, Hans H.;Gorji, Ali
神经系统并发症在接受免疫抑制剂钙调磷酸酶抑制剂治疗的移植受者中很常见。雷帕霉素是一种大环内酯类抗生素，被建议作为钙调磷酸酶抑制剂相关神经毒性（包括癫痫发作）患者的替代药物。本研究旨在检测雷帕霉素对海马CA1区生物电活性和诱发场兴奋性突触后电位（fEPSP）的影响，并与钙调磷酸酶抑制剂FK506进行比较。应用不同浓度的雷帕霉素，既不影响生物电活性，也不改变fEPSP的大小。相反，FK506引起癫痫样突发放电，显著增强fEPSP强度。这项研究支持了雷帕霉素在神经毒性事件中可作为钙调磷酸酶抑制剂的替代品的建议。
Neurological complications are common in transplant recipients treated with immunosuppressant calcineurin inhibitors. Rapamycin, a macrolide antibiotic, was suggested as an alternative agent in patients who develop calcineurin inhibitor associated neurotoxicity, including seizure attacks. The aim of the present study was to test the effect of rapamycin on the bioelectrical activity and evoked field excitatory postsynaptic potentials (fEPSP) in CA1 area of hippocampal tissues and compare its effect with FK506, a calcineurin inhibitor agent. Application of rapamycin at different concentrations neither affected the bioelectrical activity nor changed fEPSP magnitude. In contrast, FK506 elicited epileptiform burst discharges and significantly enhanced fEPSP magnitude. This study supports the suggestion that rapamycin could be used as an alternative to calcineurin inhibitors in the event of neurotoxicity.