Tumor immunogenicity and responsiveness to cancer vaccine therapy: the state of the art.

Tumor immunogenicity and responsiveness to cancer vaccine therapy: the state of the art.
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DOI:
10.1016/j.smim.2010.02.001
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发表时间:
2010-06
影响因子:
7.8
通讯作者:
Podack ER
Podack ER
中科院分区:
医学2区
文献类型:
--
作者:
Schreiber TH;Raez L;Rosenblatt JD;Podack ER

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Despite enormous effort, promising pre-clinical data in animal studies and over 900 clinical trials in the United States, no cancer vaccine has ever been approved for clinical use. Over the past decade a great deal of progress has been in both laboratory and clinical studies defining the interactions between developing tumors and the immune system. The results of these studies provide a rationale that may help explain the failure of recent therapeutic cancer vaccines in terms of vaccine principles, in selecting which tumors are the most appropriate to target and instruct the design and implementation of state-of-the-art cancer vaccines.
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