SYNTHESIS AND ABSOLUTE STEREOCHEMISTRY OF THE 2 DIASTEREOISOMERS OF P3-1-(2-NITROPHENYL)ETHYL ADENOSINE-TRIPHOSPHATE (CAGED ATP)
SYNTHESIS AND ABSOLUTE STEREOCHEMISTRY OF THE 2 DIASTEREOISOMERS OF P3-1-(2-NITROPHENYL)ETHYL ADENOSINE-TRIPHOSPHATE (CAGED ATP)
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DOI：
10.1039/p19920001015
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发表时间：
1992-04-21
期刊：
影响因子：
--
通讯作者：
MAZID, MA
中科院分区：
文献类型：
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作者：
CORRIE, JET;REID, GP;MAZID, MA
1-（2-硝基苯基）乙醇的非对映异构体（1 S）-樟脑甲酸酯经分步结晶拆分。使用Horeau动力学拆分程序确定（S）-醇的绝对立体化学，随后通过其（1 S）-樟脑甲酸酯的X射线晶体学证实。（2-硝基苯基）乙基磷酸酯，将它们各自与腺苷二磷酸缩合，得到腺苷三磷酸的（R）-和（S）-1-（2-硝基苯基）乙基β 3-酯。
1-(2-Nitrophenyl)ethanol was resolved by fractional crystallisation of its diastereoisomeric (1S)-camphanates. The absolute stereochemistry of the (S)-alcohol was determined using the Horeau kinetic resolution procedure, and subsequently confirmed by X-ray crystallography of its (1S)-camphanate ester, The resolved alcohols were converted to (R)- and (S)-1-(2-nitrophenyl)ethyl phosphates, each of which was condensed with adenosine diphosphate to give the (R)- and (S)-1-(2-nitrophenyl)ethyl P3-esters of adenosine triphosphate.