Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-tranplanted mice
Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-tranplanted mice
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DOI：
10.1634/stemcells.21-5-514
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发表时间：
2003-01-01
期刊：
影响因子：
5.2
通讯作者：
Wright, NA
中科院分区：
文献类型：
--
作者：
Direkze, NC;Forbes, SJ;Wright, NA
肌成纤维细胞是具有成纤维细胞和平滑肌细胞特征的普遍存在的细胞。我们认为，骨髓可以促进各种组织中的肌成纤维细胞群体，这是由损伤加剧。为了评估这一点，雌性小鼠移植了雄性骨髓，并在整个身体中追踪雄性细胞，并将其鉴定为肌成纤维细胞。皮肤创伤和扑热息痛管理被用来评估是否肌成纤维细胞移植受到损害。辐射、损伤后，肺、胃、食管、皮肤、肾和肾上腺囊中的一部分肌成纤维细胞是骨髓来源的。在肺中，对乙酰氨基酚给药后植入显著增加（17% vs 41% p < 0.005）。我们认为，骨髓有助于循环的细胞群，在损伤的情况下，这些细胞被招募，并有助于组织修复。
Myofibroblasts are ubiquitous cells with features of both fibroblasts and smooth muscle cells. We suggest that the bone marrow can contribute to myofibroblast populations in a variety of tissues and that this is exacerbated by injury. To assess this, female mice were transplanted with male bone marrow and the male cells were tracked throughout the body and identified as myofibroblasts. Skin wounding and paracetamol administration were used to assess whether myofibroblast engraftment was modulated by damage. Following radiation, injury, a proportion of myofibroblasts in the lung, stomach, esophagus, skin, kidney, and adrenal capsule were bone-marrow derived. In the lung, there was significantly greater engraftment following paracetamol administration (17% versus 41% p < 0.005). Bone-marrow-derived fibroblasts were also found. We suggest that bone marrow contributes to a circulating population of cells and, in the context of injury, these cells are recruited and contribute to tissue repair.