Escalating dose, multiple binge methamphetamine regimen does not impair recognition memory in rats
Escalating dose, multiple binge methamphetamine regimen does not impair recognition memory in rats
复制标题
DOI：
10.1002/syn.20397
复制
发表时间：
2007-07-01
期刊：
影响因子：
2.3
通讯作者：
Segal, David S.
中科院分区：
文献类型：
--
作者：
Clark, Robert E.;Kuczenski, Ronald;Segal, David S.
据报道，以急性高剂量“狂欢”模式暴露于甲基苯丙胺（METH）的大鼠在新物体识别（NOR）任务中表现出持续性缺陷，这可能表明人类METH滥用者存在潜在风险。然而，大多数高剂量METH滥用者最初使用较低剂量，然后逐渐增加剂量，最终只进行多次每日给药。为了模拟METH暴露的这种模式，我们在14天的间隔内给大鼠逐渐增加剂量的METH，然后每天用METH铰链治疗11天。这种治疗导致纹状体多巴胺（DA）水平持续不足20%。然后，我们在各种条件下的NOR任务中测试它们。在任何测试条件下，我们都没有发现他们在NOR任务中的表现有缺陷。这些结果表明，机制以外的或额外的纹状体DA的递减与急性METH狂欢负责的赤字在NOR任务，和神经适应随之而来的长期递增剂量的METH预处理减轻对这些机制。
Rats exposed to methamphetamine (METH) in an acute high dose "binge" pattern have been reported to exhibit a persistent deficit in a novel object recognition (NOR) task, which may suggest a potential risk for human METH abusers. However, most high dose METH abusers initially use lower doses before progressively increasing the dose, only eventually engaging in multiple daily administrations. To simulate this pattern of METH exposure, we administered progressively increasing doses of METH to rats over a 14 day interval, then treated them with daily METH hinges for 11 days. This treatment resulted in a persistent deficit in striatal dopamine (DA) levels of similar to 20%. We then tested them in a NOR task under a variety of conditions. We could not detect a deficit in their performance in the NOR task under any of the testing conditions. These results suggest that mechanisms other than or additional to the decrement in striatal DA associated with an acute METH binge are responsible for the deficit in the NOR task, and that neuroadaptations consequential to prolonged escalating dose METH pretreatment mitigate against these mechanisms.