Ursolic Acid provides kidney protection in diabetic rats.
Ursolic Acid provides kidney protection in diabetic rats.
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DOI：
10.1016/j.curtheres.2013.07.001
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发表时间：
2013-12-01
期刊：
影响因子：
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通讯作者：
Renyong, Yang
中科院分区：
文献类型：
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作者：
Ling, Chen;Jinping, Lu;Renyong, Yang
背景：糖尿病肾病（DN）是糖尿病最严重的微血管并发症之一，是终末期肾功能衰竭的主要原因。然而，DN的治疗在世界范围内仍是一个难题。炎症过程在DN的发展中起关键作用。因此，抗炎治疗DN值得现在和未来的探索。目的：研究熊果酸（UA）对链脲佐菌素所致糖尿病患者肾功能的影响。方法：用UA治疗链脲佐菌素诱导的糖尿病大鼠16周。16周后测定尿白蛋白排泄量、血清肌酐、血尿素氮。此外，评估肾脏氧化应激水平、核因子κ b （nf - κ b）活性、p -选择素表达和肾脏组织病理学变化。结果：注射链脲佐菌素16周后，大鼠肾功能发生明显改变，肾脏氧化应激、NF-kappaB活性和p -选择素表达增加。有趣的是，UA可以显著预防与糖尿病相关的肾脏生化和组织病理学变化。与未治疗的糖尿病大鼠相比，UA治疗降低了尿白蛋白排泄、肾脏氧化应激水平、NF-kappaB活性和p -选择素表达。此外，UA治疗还能改善糖尿病大鼠的肾脏组织病理学改变。结论：UA治疗对糖尿病大鼠肾脏具有保护作用，提示UA可能是糖尿病肾病的一种潜在治疗方法。
BACKGROUND: Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and the leading cause of end-stage renal failure. However, the treatment of DN is still a problem in the world. Inflammatory process plays a critical role in the development of DN. Therefore, anti-inflammatory treatment of DN is worth exploring now and in the future.OBJECTIVE: The study aimed to evaluate the impact of ursolic acid (UA) on renal function in streptozotocin-induced diabetes.METHODS: Rats with streptozotocin-induced diabetes were treated with UA for 16 weeks. After 16 weeks, urine albumin excretion, serum creatinine, and blood urea nitrogen were measured. In addition, renal oxidative stress level, nuclear factor kappa-B (NF-kappaB) activity, P-selectin expression, and kidney histopathologic changes were evaluated.RESULTS: Sixteen weeks following streptozotocin injection, the rats produced significant alteration in renal function and increased oxidative stress, NF-kappaB activity, and P-selectin expression in the kidneys. Interestingly, UA significantly prevented biochemical and histopathologic changes in the kidneys associated with diabetes. Compared with untreated diabetic rats, UA treatment lowered urine albumin excretion, renal oxidative stress level, NF-kappaB activity, and P-selectin expression. Moreover, UA treatment also improved renal histopathologic changes in rats with diabetes.CONCLUSIONS: UA treatment exhibited a protective effect on kidneys in diabetic rats, implying that UA could be a potential treatment for diabetic nephropathy.