Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease.
Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease.
复制标题
来自隐窝的故事：胃肠道稳态和疾病中的调节肽和细胞因子。
DOI：
10.1172/jci30974
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Merchant,JuanitaL
中科院分区：
文献类型：
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作者：
Merchant,JuanitaL
胃肠道（GI）由一组不同的器官组成，这些器官共同接受体外营养并将其转化为能量底物和细胞构建模块。在这个过程中，它必须对我们摄取的所有东西进行分类，区分哪些是有用的，哪些是无用的，这样做之后，它就会丢弃那些“垃圾”。为了完成这些许多不同的任务，胃肠道依赖于由肠内分泌细胞和肠神经系统产生的内源性肠激素。在许多情况下，这些任务的介质是小肽，其归巢到CNS和副肠道器官以协调口服摄入与消化分泌物。由于摄入物质的内容物可能含有有害物质，肠道拥有广泛的免疫系统。如果肠道不产生积极的免疫反应，胃肠道上皮屏障的破坏可导致局部和最终全身性疾病。
The gastrointestinal (GI) tract is composed of a diverse set of organs that together receive extracorporeal nutrition and convert it to energy substrates and cellular building blocks. In the process, it must sort through all that we ingest and discriminate what is useable from what is not, and having done that, it discards what is “junk.” To accomplish these many and varied tasks, the GI tract relies on endogenous enteric hormones produced by enteroendocrine cells and the enteric nervous system. In many instances, the mediators of these tasks are small peptides that home to the CNS and accessory gut organs to coordinate oral intake with digestive secretions. As the contents of ingested material can contain harmful agents, the gut is armed with an extensive immune system. A breach of the epithelial barrier of the GI tract can result in local and eventually systemic disease if the gut does not mount an aggressive immune response.