Biological clocks
Biological clocks
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DOI：
10.1073/pnas.96.16.8819
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发表时间：
1999-08-03
影响因子：
11.1
通讯作者：
Allada, R
中科院分区：
文献类型：
--
作者：
Ishida, N;Kaneko, M;Allada, R
昼夜节律描述了以近似24小时周期振荡的生物现象。这些节律包括血压、体温、激素水平、血液中免疫细胞的数量以及睡眠-觉醒周期，在本文中，我们将重点关注物种之间负责决定昼夜节律行为的共同基因，特别是一些转录因子（即，开关基因），其用于调节许多昼夜节律基因。本摘要的目的是介绍苍蝇和人类之间生物钟的共同分子机制，然后描述会议上提出的三个实验室的研究。
Circadian rhythms describe biological phenomena that oscillate with an approximate to 24-hour cycle. These rhythms include blood pressure, body temperature, hormone levels, the number of immune cells in blood, and the sleep-wake cycle, In this paper, we will focus on common genes between species that are responsible for determining the circadian behavior, especially some transcription factors (i.e., switch genes) that serve to regulate many circadian rhythm genes. The intent of this summary is to introduce the common molecular mechanism of biological clocks between flies and humans and then to describe the research from three laboratories that was presented in the session.