The determination of bupivacaine, lignocaine and mepivacaine in human blood
The determination of bupivacaine, lignocaine and mepivacaine in human blood
复制标题
人血液中布比卡因、利多卡因和甲哌卡因的测定
DOI：
--
复制
发表时间：
1968
期刊：
影响因子：
--
通讯作者：
A. Beckett
中科院分区：
文献类型：
--
作者：
F. Reynolds;A. Beckett
描述了一种使用气液色谱法定量分析血液中布比卡因、利多卡因和甲哌卡因（临床浓度）的特定方法。提取程序的回收率为97.5（±5）%，色谱条件允许测量2 ml全血中低至0.04 μg/ml的局部麻醉剂浓度。该方法的标准偏差为5.4%。未遇到常用术前用药或全身麻醉药物的干扰。
A specific method for the quantitative analysis of bupivacaine, lignocaine and mepivacaine in blood, in clinically occurring concentrations, using gas‐liquid chromatography, is described. The extraction procedure yields a recovery of 97·5 (±5)%, and the chromatographic conditions allow concentrations as low as 0·04 μg/ml of local anaesthetic in 2 ml of whole blood to be measured. The method has a standard deviation of 5·4%. No interference is encountered from commonly used premedicant or general anaesthetic drugs.