The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations.
The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations.
复制标题
DOI：
10.1375/twin.3.3.152
复制
发表时间：
2000-09-01
期刊：
影响因子：
--
通讯作者：
Princen, H M
中科院分区：
文献类型：
--
作者：
Boomsma, D I;Knijff, P;Princen, H M
载脂蛋白(a)、载脂蛋白- e和载脂蛋白- a4同型体对定量脂蛋白(a) [Lp(a)]水平的影响在142个荷兰家庭样本中进行了评估，这些家庭由双亲及其青春期的双胞胎子女组成。血浆Lp(A)浓度的总遗传率估计为95%。这种遗传力的最大部分是由于载脂蛋白(a)位点，它解释了Lp(a)水平总方差的61%。Lp(a)变异剩余部分的家族相关性模式不能归因于载脂蛋白(a)同种异构体，这表明遗传对剩余变异有影响。我们解决了这个问题是否残留的遗传变异可以归因于apoE或apoA4位点。同时对这三个基因座的分析表明，apoE和apoA4多态性对Lp(A)变异没有显著影响。
The effects of apolipoprotein (a), apolipoprotein-E, and apolipoprotein-A4 isoforms on quantitative lipoprotein(a) [Lp(a)] levels were assessed in a sample of 142 Dutch families consisting of two parents and their adolescent twin offspring. A total heritability of 95% was estimated for plasma Lp(a) concentrations. The largest part of this heritability was due to the apo(a) locus which explained 61% of the total variance in Lp(a) levels. The pattern of familial correlations for the residual part of the Lp(a) variance that could not be attributed to the apo(a) isoforms, suggested genetic influences on the residual variance. We addressed the question whether this residual genetic variance could be ascribed to the apoE or the apoA4 locus. A simultaneous analysis of all three loci showed that both the apoE and the apoA4 polymorphism did not contribute significantly to Lp(a) variation.