Arp2/3 mediates early endosome dynamics necessary for the maintenance of PAR asymmetry in Caenorhabditis elegans
Arp2/3 mediates early endosome dynamics necessary for the maintenance of PAR asymmetry in Caenorhabditis elegans
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DOI：
10.1091/mbc.e12-01-0006
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发表时间：
2012-05
影响因子：
3.3
通讯作者：
Jessica M. Shivas;Ahna R. Skop
中科院分区：
文献类型：
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作者：
Jessica M. Shivas;Ahna R. Skop
秀丽隐杆线虫Arp 2的耗竭破坏PAR不对称性的维持、内吞标记物的皮质募集和早期内体动力学。观察到与早期内体相关的大的细胞质PAR聚集体，表明Arp 2/3调节PAR从早期内体的再循环以稳定不对称性的模型。
Depletion of Caenorhabditis elegans Arp2 disrupts PAR asymmetry maintenance, cortical recruitment of endocytic markers, and early endosomal dynamics. Large cytoplasmic PAR aggregates are observed in association with early endosomes, suggesting a model in which Arp2/3 regulates recycling of PARs from the early endosome to stabilize the asymmetry.