EPIDEMIOLOGIC EVIDENCE FOR THE DEVELOPMENT OF SEROVAR-SPECIFIC IMMUNITY AFTER GONOCOCCAL-INFECTION
EPIDEMIOLOGIC EVIDENCE FOR THE DEVELOPMENT OF SEROVAR-SPECIFIC IMMUNITY AFTER GONOCOCCAL-INFECTION
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DOI：
10.1172/jci114040
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发表时间：
1989-05-01
影响因子：
15.9
通讯作者：
NGUGI, EN
中科院分区：
文献类型：
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作者：
PLUMMER, FA;SIMONSEN, JN;NGUGI, EN
我们对居住在一个小社区的227名经常感染淋球菌的妓女进行了纵向研究，检验了菌株特异性免疫在淋球菌感染后发生的假设。每隔2周对妇女进行淋病奈瑟菌检查和培养。淋球菌分离株根据蛋白1血清型、生长型和β-内酰胺酶质粒型进行分型，并按血清型和菌株进行分类。通过将假设的预测与研究的观察结果进行比较，对该假设进行了检验。在14个月的研究期间，在感染这些妇女的淋球菌群中观察到特定血清型流行率的主要变化。与HIV阴性的女性相比，感染HIV的女性淋球菌感染率更高(0.56±0.03比0.46±0.04，P<；0.05，t检验)，并且最有可能经历同一菌株的多重感染。卖淫的持续时间与淋球菌感染的频率成反比。感染了特定淋球菌血清型的妇女，除1B-1血清型外，再次感染相同血清型的风险降低了2-10倍。这项研究的结果与假设的所有四个预测一致。感染特定的淋球菌血清型会导致特定但不完全的保护，以防止随后感染同源的血清型。这种保护的机制还有待确定。
We tested the hypothesis that strain-specific immunity occurs after genococcal infection in a longitudinal study of 227 prostitutes resident in one small community who experienced frequent gonococcal infections. Women were examined and cultured for Neisseria gonorrhoeae at 2-wk intervals. Gonococcal isolates were typed according to protein 1 serovar, auxotype, and .beta.-lactamase plasmid type, and classified as to serovar and strain. The hypothesis was tested by comparing the predictions of the hypothesis with the observations of the study. Over the 14-mo period of the study, major changes in the prevalence of specific serovars were observed in the gonococcal population infecting these women. Women with HIV infeciton experienced a higher rate of gonococcal infection (0.56.+-.0.03 vs. 0.46.+-.0.04, P < 0.05, t test) compared with HIV-negative women and were most likely to experience multiple infections with the same strain. The duration of prostitution was inversely related to the frequency of gonococcal infection. Women experiencing an infection with a specific gonococcal serovar were at a 2- to 10-fold reduced risk for reinfection with the same serovar, except for the 1B-1 serovar. The results of the study were consistent with all four predictions of the hypothesis. Infection with a specific gonococcal serovar results in specific but incomplete protection against subsequent infection with the homologous serovar. The mechanism of this protection remains to be determined.