Cortical State Fluctuations across Layers of V1 during Visual Spatial Perception.
Cortical State Fluctuations across Layers of V1 during Visual Spatial Perception.
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视觉空间感知过程中 V1 层的皮质状态波动。
DOI：
10.1016/j.celrep.2019.02.045
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发表时间：
2019
期刊：
影响因子：
8.8
通讯作者：
Haider,Bilal
中科院分区：
文献类型：
--
作者：
Speed,Anderson;DelRosario,Joseph;Burgess,ChristopherP;Haider,Bilal
许多因素调节皮质活动的状态，但皮质状态变异性对感觉知觉的重要性仍然存在争议。我们训练小鼠检测空间定位的视觉刺激，并同时测量局部场电位和兴奋性和抑制性神经元群体的初级视觉皮层（V1）层。皮质状态与低自发放电和兴奋性神经元的相关性，并抑制3- 7-Hz的振荡层4，准确地预测单次试验的视觉检测。我们的研究结果表明，皮质状态在V1的皮质加工的初始阶段产生强烈的影响，并可以在小鼠的视觉空间行为中发挥突出的作用。
Many factors modulate the state of cortical activity, but the importance of cortical state variability for sensory perception remains debated. We trained mice to detect spatially localized visual stimuli and simultaneously measured local field potentials and excitatory and inhibitory neuron populations across layers of primary visual cortex (V1). Cortical states with low spontaneous firing and correlations in excitatory neurons, and suppression of 3- to 7-Hz oscillations in layer 4, accurately predicted single-trial visual detection. Our results show that cortical states exert strong effects at the initial stage of cortical processing in V1 and can play a prominent role for visual spatial behavior in mice.