Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13
Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13
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DOI：
10.1097/01.ypg.0000107927.32051.f5
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发表时间：
2004-06-01
影响因子：
0.9
通讯作者：
Gurling, HMD
中科院分区：
文献类型：
--
作者：
Curtis, D;Brett, P;Gurling, HMD
目的 定位影响易感性的基因，三个阳性区域最终与吉尔·德拉抽动秽语综合征 (GTS) 相关，并且至少一个区域可能包含慢性多发性抽动症 (CMT) 易感性。轨迹。我们建议进行基于关联的研究。 方法 对包含 35 名诊断为 GTS 的受试者和另外 14 名患有 CMT 的受试者的单一、大型、多重受影响的谱系进行了跨常染色体标记的基因分型。使用经典的lod评分分析和无模型lod评分分析进行连锁分析。所有标记均进行两点分析，产生两点结果的标记在 P 处显着
Objectives To localize genes influencing the susceptibility three positive regions is conclusively implicated, to Gilles de la Tourette syndrome (GTS) and associated it seems probable that at least one contains a susceptibility chronic multiple tics (CMT). locus. We recommend that association-based studies.Method A single, large, multiple affected pedigree containing 35 subjects diagnosed with GTS and a further 14 with CMT was genotyped for markers spanning the autosomes. Linkage analysis was carried out using classical lod score analysis and model-free lod score analysis. All markers were subjected to two-point analysis, and markers producing a two-point result significant at P