Impact of Alcohol on Bone Health, Homeostasis and Fracture repair.
Impact of Alcohol on Bone Health, Homeostasis and Fracture repair.
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DOI：
10.1007/s40139-020-00209-7
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发表时间：
2020-09
影响因子：
--
通讯作者：
Callaci JJ
中科院分区：
文献类型：
--
作者：
Eby JM;Sharieh F;Callaci JJ
酒精使用在全球范围内持续上升。我们回顾了目前关于酒精对骨骼健康、体内平衡和骨折修复的影响的文献，以强调在人类和动物饮酒模型中所学到的东西。最近，叉头框O（FoxO）已被发现上调和激活间充质干细胞（MSC）暴露于酒精。还发现FoxO调节Wnt/β-连环蛋白信号传导，这是MSC分化所必需的。最近的证据表明，酒精激活FoxO信号传导，其可能在酒精中培养的MSC中失调Wnt/β-连环蛋白信号传导。这篇综述强调了从人类和慢性和间歇性酗酒动物模型中学到的负面健康影响。使用慢性酒精暴露或酒精暴露然后骨折修复模型的研究已经探索了几种不同的细胞和分子信号通路，这些通路对骨稳态和骨折修复很重要，并为未来的实验提供了潜力，以探索可能因酒精暴露而失调的其他信号通路。
Alcohol use continues to rise globally. We review the current literature on the effect of alcohol on bone health, homeostasis and fracture repair to highlight what has been learned in people and animal models of alcohol consumption. Recently, forkhead box O (FoxO) has been found to be upregulated and activated in mesenchymal stem cells (MSC) exposed to alcohol. FoxO has also been found to modulate Wnt/β-catenin signaling, which is necessary for MSC differentiation. Recent evidence suggests alcohol activates FoxO signaling, which may be dysregulating Wnt/β-catenin signaling in MSCs cultured in alcohol. This review highlights the negative health effects learned from people and chronic and episodic binge alcohol consumption animal models. Studies using chronic alcohol exposure or alcohol exposure then bone fracture repair model have explored several different cellular and molecular signaling pathways important for bone homeostasis and fracture repair, and offer potential for future experiments to explore additional signaling pathways that may be dysregulated by alcohol exposure.
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DOI：
10.1111/acer.13284
发表时间：
2017-01
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Alund AW;Mercer KE;Pulliam CF;Suva LJ;Chen JR;Badger TM;Ronis MJ
通讯作者：
Ronis MJ
影响因子：
4.7
作者：
Carnero A;Paramio JM
通讯作者：
Paramio JM
影响因子：
2.8
作者：
Alvisa-Negrin, Julio;Gonzalez-Reimers, Emilio;de los Angeles Gomez-Rodriguez, Maria
通讯作者：
de los Angeles Gomez-Rodriguez, Maria
酒精会诱导细胞衰老并损害骨髓间充质干细胞的成骨潜力。
影响因子：
2.8
作者：
Chen, Xi;Li, Mao;He, Fan
通讯作者：
He, Fan
DOI：
10.1359/jbmr.081011
发表时间：
2009-02
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Chen JR;Lazarenko OP;Haley RL;Blackburn ML;Badger TM;Ronis MJ
通讯作者：
Ronis MJ