COMPARATIVE POTENCIES OF AMPHETAMINE, FENFLURAMINE AND RELATED COMPOUNDS IN TASTE-AVERSION EXPERIMENTS IN RATS
COMPARATIVE POTENCIES OF AMPHETAMINE, FENFLURAMINE AND RELATED COMPOUNDS IN TASTE-AVERSION EXPERIMENTS IN RATS
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DOI：
10.1111/j.1476-5381.1977.tb07560.x
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发表时间：
1977-01-01
影响因子：
7.3
通讯作者：
STOLERMAN, IP
中科院分区：
文献类型：
--
作者：
BOOTH, DA;PILCHER, CWT;STOLERMAN, IP
1.大鼠在食用调味溶液后注射安非他明（条件性味觉厌恶），但未能饮用调味溶液。（2）（+）-和（-）-安非他明的效力差别很小。3 p-氯甲基苯丙胺是比甲基苯丙胺更有效的厌恶剂。[4]强烈的味觉厌恶也与苯丙胺的其他同类物有关。其效力大小顺序为：芬氟拉明>氯苯丁胺>对羟基苯丙胺。5.即使在高剂量下，可卡因也只引起中等程度的味觉厌恶。6.厌恶效能似乎与药物的已知神经化学作用或行为刺激无关，但似乎是一种中枢作用，可能与促兴奋效能或作用时间进程有关。
1 Rats failed to drink a flavoured solution when its consumption had been followed by injection of amphetamine (conditioned taste aversion). 2 There was very little difference between the potencies of (+)- and (-)-amphetamine. 3 p-Chloromethamphetamine was a more potent aversive agent than methamphetamine. 4 Strong taste aversions were also conditioned with other congeners of amphetamine. The rank order of potency was: fenfluramine > chlorphentermine >p-hydroxyamphetamine. 5 Cocaine induced only moderate taste aversions, even at high doses. 6 Aversive potency did not appear to be correlated with known neurochemical actions of the drugs or with behavioural stimulation, but appeared to be a central action which may have been linked to anorexigenic potency or time course of action.