Food, splanchnic blood flow, and bioavailability of drugs subject to first‐pass metabolism
Food, splanchnic blood flow, and bioavailability of drugs subject to first‐pass metabolism
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DOI：
10.1002/cpt19782415
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发表时间：
1978-07
影响因子：
6.7
通讯作者：
A. Mclean;P. McNamara;P. duSouich;M. Gibaldi;D. Lalka
中科院分区：
文献类型：
--
作者：
A. Mclean;P. McNamara;P. duSouich;M. Gibaldi;D. Lalka
在过去的15年里，人们对确定食物和饮食对胃肠道药物吸收的影响有相当大的兴趣。Welling21最近对这些努力进行了全面和批判性的审查。一般来说，食物会降低药物从胃肠道的吸收率，但在大多数情况下对吸收程度的影响很小。这种效应对于镇静催眠药和其他需要迅速反应的药物具有临床意义，但在大多数其他情况下可能不太重要。另一方面，食物被发现大大减少了某些药物的吸收程度，包括许多抗生素。这种类型的食物效应通常发生在渗透性差的药物中，即使禁食患者也不能完全吸收。与餐时连续给予此类药物将导致血浆中的稳态药物浓度低于空腹状态下给予药物时的浓度。
There has been considerable interest in the past fifteen years in determining the influence of food and diet on gastrointestinal drug absorption. Welling21 has recently presented a comprehensive and critical review of these efforts. In general, food reduces the absorption rate of drugs from the gastrointestinal tract but in most instances has little influence on the extent of absorption. Such an effect is clinically significant for sedative‐hypnotics and for other drugs where a prompt response is desired but is probably of little concern in most other cases. On the other hand, food has been found to substantially reduce the extent of absorption of certain drugs, including many antibiotics. This type of food effect often occurs with drugs with poor permeability characteristics that are incompletely absorbed even by fasting patients. Continual administration of such drugs with meals would result in lower steady‐state drug concentrations in plasma than would be found were the drug to be given under fasting conditions.