Controlled release of atenolol from the ethylene-vinyl acetate matrix
Controlled release of atenolol from the ethylene-vinyl acetate matrix
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DOI：
10.1016/j.ijpharm.2003.12.004
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发表时间：
2004-04-01
影响因子：
5.8
通讯作者：
Shin, SC
中科院分区：
文献类型：
--
作者：
Kim, J;Shin, SC
本研究旨在评估使用聚合物 EVA 膜作为 EVA 基质系统用于阿替洛尔透皮递送的可能性。研究了阿替洛尔-EVA 基质中药物浓度、温度和增塑剂对药物释放的影响。药物从 EVA 基质中的释放速率随着温度和载药剂量的增加而增加。阿替洛尔的通量与负荷剂量的倒数形成一条直线。阿替洛尔从 EVA 基质中的释放遵循扩散控制模型，其中每单位面积释放的量与时间的平方根成正比。在使用的柠檬酸烷基酯和邻苯二甲酸酯等增塑剂中，柠檬酸三丁酯（TBC）表现出最好的增强效果。 37°C 下 EVA 基质的 TBC 增强系数为 1.51。阿替洛尔系统的控释可以使用包含增塑剂的EVA聚合物来开发。 (C) 2004 Elsevier B.V. 保留所有权利。
The present study was carried out to evaluate the possibility of using the polymer EVA membrane as an EVA matrix system for transdermal delivery of atenolol. The effects of drug concentration, temperature, and plasticizers on drug release were studied from the atenolol-EVA matrix. The release rate of drug from the EVA matrix increased with increased temperature and drug loading doses. The flux of atenolol versus the reciprocal of the loading dose yielded a straight line. The release of atenolol from the EVA matrix follows a diffusion-controlled model, where the quantity released per unit area is proportional to the square root of time. Among the plasticizers used such as alkyl citrates and phthalates, tributyl citrate (TBC) showed the best enhancing effects. Enhancement factor of TBC was 1.51 from the EVA matrix at 37degreesC. The controlled release of atenolol system could be developed using the EVA polymer including the plasticizer. (C) 2004 Elsevier B.V. All rights reserved.