EXPERIMENTAL PROTEIN-ENERGY MALNUTRITION IN BABY BABOONS - ATTEMPTS TO REPRODUCE PATHOLOGICAL FEATURES OF KWASHIORKOR AS SEEN IN UGANDA
EXPERIMENTAL PROTEIN-ENERGY MALNUTRITION IN BABY BABOONS - ATTEMPTS TO REPRODUCE PATHOLOGICAL FEATURES OF KWASHIORKOR AS SEEN IN UGANDA
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DOI：
10.1079/bjn19720029
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发表时间：
1972-01-01
影响因子：
3.6
通讯作者：
WHITEHEAD, RG
中科院分区：
文献类型：
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作者：
COWARD, DG;WHITEHEAD, RG
Grady，Higginson & Svoboda，1966）指出，狒狒，一种常见的乌干达当地动物，可能提供一个更现实的模型。我们决定，对于我们的特殊需要，只有当最终发展出的病理状态与恶性营养不良症非常相似，以至于经验丰富的儿科医生在诊断这种疾病时没有困难时，动物模型才能被认为是合适的。乌干达恶性营养不良症的主要特征是水肿、生长障碍、稀疏的浅色头发、肌肉萎缩、皮肤苍白（有时显示出片状皮肤病）、脂肪肝和严重的痛苦（Dean和Jelliffc，1960年）。这项研究的主要目的是设计一个在动物模型中产生这些症状的系统，同时也被认为重要的是，病理变化应该在尽可能类似于患恶性营养不良症的乌干达儿童的饮食条件下产生。除了在狒狒中进行这项调查外，还开始了一项前瞻性纵向研究，以描述与乌干达营养不良相关的基本环境因素。基于这些信息的变化逐渐纳入原始实验饮食计划。
Grady, Higginson & Svoboda, 1966) indicated that the baboon, a common local animal in Uganda, might provide a more realistic model. We decided that for our particular needs an animal model could only be considered suitable if a pathological state eventually developed that resembled kwashiorkor SO closely that an experienced paediatrician would have no difficulty in diagnosing the condition. The principal features of kwashiorkor in Uganda are ocdema, failure of growth, sparse light-coloured hair, wasted muscles, pallor of the skin which sometimes shows a flaky-paint dermatosis, a fatty liver and gross misery (Dean & Jelliffc, 1960). The main aim of this investigation was to devise a system for producing these signs in the animal model.It was also thought important that the pathological changes should be produced under dietary circumstances as similar as possible to those of the Ugandan child who gets kwashiorkor. Parallcl with this investigation in baboons, a prospective longitudinal study was started to characterize the essential environmental factors associated with malnutrition in Uganda. Changes, based on this information, were gradually incorporated into the original experimental dietary schedule.