Inhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype?
Inhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype?
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DOI：
10.1017/s003329170999033x
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发表时间：
2010-02
影响因子：
6.9
通讯作者：
Sahakian BJ
中科院分区：
文献类型：
--
作者：
Morein-Zamir S;Fineberg NA;Robbins TW;Sahakian BJ
强迫症（OCD）与以下方面的损害有关： 停止信号抑制，一种运动反应抑制的测量方法。研究 我使用了一种新的范式来研究思维抑制和反应 强迫症的抑制，其中与强迫症相关的刺激的调节作用 也可以评估。此外，该研究还比较了抑制 强迫症患者的损害与共病抑郁症， 抑郁症是强迫症的主要合并症。意志反应抑制和无意识思维抑制 使用一种新的思维停止信号检查情绪和中性刺激 任务对非抑郁强迫症患者进行思维停止信号任务 强迫症患者、抑郁症患者和健康对照组（n=20 每组）。运动抑制障碍在强迫症患者中是明显的，而运动抑制障碍在强迫症患者中是明显的。 反应表现在患者和对照组之间没有差异。切换 对一个新的反应，但不运动抑制的影响，由刺激 与强迫症患者的关系此外，无意的思想抑制 如通过重复引发测量的是完整的。强迫症患者， 抑郁症在任何任务绩效指标上都没有差异，尽管 在所有自我报告的测量中都存在显着差异。结果支持强迫症的运动抑制缺陷保持稳定 不管刺激的意义或共病抑郁症。只有切换到 新反应受刺激意义的影响。当反应抑制 在强迫症患者中是成功的，所以是无意中抑制的。 伴随思想。
Obsessive-compulsive disorder (OCD) has been associated with impairments in stop-signal inhibition, a measure of motor response suppression. The study used a novel paradigm to examine both thought suppression and response inhibition in OCD, where the modulatory effects of stimuli relevant to OCD could also be assessed. Additionally, the study compared inhibitory impairments in OCD patients with and without co-morbid depression, as depression is the major co-morbidity of OCD. Volitional response suppression and unintentional thought suppression to emotive and neutral stimuli were examined using a novel thought stop-signal task. The thought stop-signal task was administered to non-depressed OCD patients, depressed OCD patients and healthy controls (n=20 per group). Motor inhibition impairments were evident in OCD patients, while motor response performance did not differ between patients and controls. Switching to a new response but not motor inhibition was affected by stimulus relevance in OCD patients. Additionally, unintentional thought suppression as measured by repetition priming was intact. OCD patients with and without depression did not differ on any task performance measures, though there were significant differences in all self-reported measures. Results support motor inhibition deficits in OCD that remain stable regardless of stimulus meaning or co-morbid depression. Only switching to a new response was influenced by stimulus meaning. When response inhibition was successful in OCD patients, so was the unintentional suppression of the accompanying thought.