Ca2+-binding protein S100A11: A novel diagnostic marker for breast carcinoma
Ca2+-binding protein S100A11: A novel diagnostic marker for breast carcinoma
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DOI：
10.3892/or_00000764
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发表时间：
2010-05-01
期刊：
影响因子：
4.2
通讯作者：
Fan, Zhi-Min
中科院分区：
文献类型：
--
作者：
Liu, Xiang-Guo;Wang, Xiao-Ping;Fan, Zhi-Min
为了评价S100A11是否可以作为一种新的乳腺癌诊断标志物，采用差异蛋白质组学方法。Western blotting和免疫组化检测S100A11的表达模式和亚细胞定位。统计分析表明，A100A11特异性上调与年龄、肿瘤大小、分级分期、ER、PR、HER-2、淋巴结状态等预后因素无关。我们的数据支持S100A11是一种新的乳腺癌诊断标志物。分析S100A11在乳腺癌中的表达可能是早期乳腺癌检测的有效工具。
To evaluate whether S100A11 could be considered to be a novel diagnostic marker in breast carcinoma, the method of differential proteomics. Western blotting, and immunohistochemistry were used to detect the expression pattern and subcellular localization of S100A11. Statistical analyses indicated that specific up-regulated of A100A11 did not correlate with other prognostic factors such as age, tumor size, grade and stage, ER, PR, HER-2 and nodal status. Our data support that S100A11 is a novel diagnostic marker in breast carcinoma. Analysis of S100A11 expression in breast cancer may be an effective tool help in detection of early-stage breast cancer.