Clinical Characteristics of Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction
Clinical Characteristics of Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction
复制标题
DOI：
10.1161/circheartfailure.110.958801
复制
发表时间：
2011-05-01
影响因子：
9.7
通讯作者：
Rich, Stuart
中科院分区：
文献类型：
--
作者：
Thenappan, Thenappan;Shah, Sanjiv J.;Rich, Stuart
背景-肺血管疾病伴左心衰和射血分数保留（PH-HFpEF）是肺动脉高压的一个越来越常见的原因。PH-HFpEF和肺动脉高压（PAH）之间的区别很重要，因为适用于PAH的治疗在HFpEF中可能是有害的。PH-HFpEF的特点是understudied.Methods和Results-In一项横断面研究，我们比较了临床，超声心动图，和血流动力学特征的PH-HFpEF（n=100），肺动脉高压（n=522），HFpEF无肺血管疾病（n=45）。我们确定了最能区分PH-HFpEF和PAH的临床特征。与PAH患者相比，PH-HFpEF患者年龄更大;心血管合并症的患病率更高;运动能力和肾功能更差;左心房增大的频率更高;右心房增大的频率更低。PH-HFpEF患者的PH严重程度低于PAH患者（肺血管阻力4.8 [四分位数范围3至8.4] vs 10.9 [四分位数范围7.4至15.7] Wood单位; P
Background-Pulmonary vascular disease associated with left-side heart failure and preserved ejection fraction (PH-HFpEF) is an increasingly common cause of pulmonary hypertension. The distinction between PH-HFpEF and pulmonary arterial hypertension (PAH) is important because therapies indicated for PAH can be detrimental in HFpEF. The characteristic features of PH-HFpEF are understudied.Methods and Results-In a cross-sectional study, we compared the clinical, echocardiographic, and hemodynamic features of PH-HFpEF (n=100), with PAH (n=522), and HFpEF without pulmonary vascular disease (n=45). We determined the clinical characteristics that best differentiated PH-HFpEF from PAH. Compared with patients with PAH, patients with PH-HFpEF were older; had a higher prevalence of cardiovascular comorbidities; had worse exercise capacity and renal function; more frequently had left atrial enlargement; and less frequently had right atrial enlargement. PH was less severe in PH-HFpEF patients than in PAH patients (pulmonary vascular resistance 4.8 [interquartile range 3 to 8.4] versus 10.9 [interquartile range 7.4 to 15.7] Wood units; P