Cell polarity linked to gravity sensing is generated by LZY translocation from statoliths to the plasma membrane
Cell polarity linked to gravity sensing is generated by LZY translocation from statoliths to the plasma membrane
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DOI：
10.1126/science.adh9978
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发表时间：
2023-09-01
期刊：
影响因子：
56.9
通讯作者：
Morita，Miyo Terao
中科院分区：
文献类型：
--
作者：
Nishimura，Takeshi;Mori，Shogo;Morita，Miyo Terao
生物在重力的作用下进化，许多生物通过特殊细胞中的平衡石来感知重力的方向。在开花植物中，淀粉积累质体，称为造粉体，作为平衡石，以促进下游向重力性。重力感应机制长期以来一直被认为是一种机械感应过程，淀粉体通过该过程将力传递到细胞内结构，但其分子机制尚未阐明。我们在这里表明，LAZY1样（LZY）家族蛋白参与平衡细胞重力信号与造淀粉体和近端质膜。这导致根据重力方向的极定位。我们提出了一种重力感应机制，通过这种机制，LZY易位到质膜通过传递淀粉体位置的信息来发出重力方向的信号。
Organisms have evolved under gravitational force, and many sense the direction of gravity by means of statoliths in specialized cells. In flowering plants, starch-accumulating plastids, known as amyloplasts, act as statoliths to facilitate downstream gravitropism. The gravity-sensing mechanism has long been considered a mechanosensing process by which amyloplasts transmit forces to intracellular structures, but the molecular mechanism underlying this has not been elucidated. We show here that LAZY1-LIKE (LZY) family proteins involved in statocyte gravity signaling associate with amyloplasts and the proximal plasma membrane. This results in polar localization according to the direction of gravity. We propose a gravity-sensing mechanism by which LZY translocation to the plasma membrane signals the direction of gravity by transmitting information on the position of amyloplasts.