Dopamine Receptors Differentially Enhance Rule Coding in Primate Prefrontal Cortex Neurons
Dopamine Receptors Differentially Enhance Rule Coding in Primate Prefrontal Cortex Neurons
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DOI：
10.1016/j.neuron.2014.11.012
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发表时间：
2014-12-17
期刊：
影响因子：
16.2
通讯作者：
Nieder, Andreas
中科院分区：
文献类型：
--
作者：
Ott, Torben;Jacob, Simon Nikolas;Nieder, Andreas
灵活应用抽象规则是前额皮质（PFC）神经元代表的执行功能的标志特征。前额叶网络受到神经调节剂多巴胺的调节，但多巴胺如何调节高级执行功能仍然难以捉摸。在执行基于规则的决策任务的猴子中，我们报告多巴胺 D1 和 D2 受体均促进 PFC 神经元的规则编码，尽管其生理机制不同。多巴胺 D1 受体刺激抑制神经元放电，同时增加对首选规则的反应，从而增强神经元规则编码。相反，D2 受体刺激会刺激神经元放电，同时抑制对非首选规则的反应，从而也增强神经元规则编码。这些发现强调了多巴胺受体对介导执行功能和目标导向行为的神经元回路的互补调节作用。
Flexibly applying abstract rules is a hallmark feature of executive functioning represented by prefrontal cortex (PFC) neurons. Prefrontal networks are regulated by the neuromodulator dopamine, but how dopamine modulates high-level executive functions remains elusive. In monkeys performing a rule-based decision task, we report that both dopamine D1 and D2 receptors facilitated rule coding of PFC neurons, albeit by distinct physiological mechanisms. Dopamine D1 receptor stimulation suppressed neuronal firing while increasing responses to the preferred rule, thereby enhancing neuronal rule coding. D2 receptor stimulation, instead, excited neuronal firing while suppressing responses to the nonpreferred rule, thus also enhancing neuronal rule coding. These findings highlight complementary modulatory contributions of dopamine receptors to the neuronal circuitry mediating executive functioning and goal-directed behavior.