Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides
Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides
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DOI：
10.1016/s0040-4039(98)01084-3
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发表时间：
1998-07-23
影响因子：
1.8
通讯作者：
Imanishi, T
中科院分区：
文献类型：
--
作者：
Obika, S;Nanbu, D;Imanishi, T
将具有固定N型构象的双环核苷类似物2 ′-O，4 ′-C-亚甲基尿苷和-胞苷掺入寡核苷酸中，研究了修饰后的寡核苷酸与互补DNA和RNA的结合效率以及修饰后的DNA-DNA和DNA-RNA双链体的CD谱。(C)1998爱思唯尔科技有限公司版权所有。
Bicyclic nucleoside analogues with a fixed N-type conformation, 2'-O,4'-C-methyleneuridine and -cytidine, were incorporated into oligonucleotides, and the binding efficiency of the modified oligonucleotides to the complementary DNA and RNA as well as the CD spectra of the modified DNA-DNA and modified DNA-RNA duplexes were studied. (C) 1998 Elsevier Science Ltd. All rights reserved.