Influence of Fluoride Contamination on Titanium Surface on Cell Viability and Cell Differentiation of ES-D3 Cells
Influence of Fluoride Contamination on Titanium Surface on Cell Viability and Cell Differentiation of ES-D3 Cells
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钛表面氟化物污染对ES-D3细胞活力和细胞分化的影响
DOI：
10.11223/jarde.15.35
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Nishikawa T.
中科院分区：
文献类型：
--
作者：
Imai K;Zennyu K;Yoshida T;Ono Y;Kumabe S;Nishikawa T.
化学物质的发育毒性严重损害人类新生儿的正常出生。在酸化产生的氟离子存在的情况下，用于种植体固定装置的钛的耐腐蚀性大大降低。据我们所知，氟化物腐蚀钛表面形成的腐蚀产物的细胞毒性和发育毒性尚未见报道。因此，我们研究ES-D3细胞的分化和增殖，这是EST方法中使用的一个参数。氢氟酸溶液腐蚀JIS 1类和2类钛板表面，影响细胞的分化和增殖。需要澄清的是，虽然这一发现不会直接导致临床发育毒性，但也有必要研究用于种植体固定装置的钛合金的腐蚀情况。
Developmental toxicity of chemical substances seriously impairs normal birth of human newborns. Corrosion resistance of titanium used in implant fixtures extremely decreases in the presence of fluorine ion produced by acidification. To our knowledge, cytotoxicity and developmental toxicity of corrosion products formed by corrosion of the titanium surface by fluoride have not been reported. Thus, we investigated differentiation and proliferation of ES-D3 cells, which is a parameter employed in the EST method. When the surfaces of JIS Class 1 and 2 titanium plates were corroded with hydrofluoric acid solution, cell differentiation and proliferation were affected. It was clarified that although this finding does not directly lead to clinical developmental toxicity, it is also necessary to investigate corrosion of titanium alloys used in implant fixtures.