Abnormal Degree Centrality as a Potential Imaging Biomarker for Right Temporal Lobe Epilepsy: A Resting-state Functional Magnetic Resonance Imaging Study and Support Vector Machine Analysis
Abnormal Degree Centrality as a Potential Imaging Biomarker for Right Temporal Lobe Epilepsy: A Resting-state Functional Magnetic Resonance Imaging Study and Support Vector Machine Analysis
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DOI：
10.1016/j.neuroscience.2022.02.004
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发表时间：
2022-03-01
期刊：
影响因子：
3.3
通讯作者：
Li, Dongbin
中科院分区：
文献类型：
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作者：
Gao, Yujun;Xiong, Zhenying;Li, Dongbin
以往的研究报道了右颞叶癫痫（rTLE）的神经影像学特征改变。然而，程度中心性（DC）的变化作为rTLE的诊断方法尚未报道。因此，我们的目的是探讨异常的DC的rTLE和这种改变是否可以应用于诊断rTLE。采用静息态功能磁共振成像（fMRI）对82例rTLE患者和69例健康对照者进行扫描。DC和支持向量机（SVM）的方法被用来分析的成像数据。与对照组相比，rTLE患者在右侧大脑半球、右侧上级颞回和右侧尾状核的DC值较低。与对照组相比，rTLE患者在右侧额内侧上级回（SFGmed）、左侧额背外侧上级回（SFGdor）、右侧顶下小叶（IPL）和左侧中央后叶的DC值较高。SVM对rTLE患者和正常对照组的诊断准确率最高，分别为99.34%（150/151）、沿着100%（82/82）和98.55%（68/69）。该研究证实了rTLE患者的功能连接异常。因此，一个独特的DC模式可以作为诊断rTLE患者的成像标志物。(c)2022 IBRO。由爱思唯尔有限公司出版。保留所有权利。
Previous studies have reported altered neuroimaging features in right temporal lobe epilepsy (rTLE). However, the alterations in degree centrality (DC) as a diagnostic method for rTLE have not been reported. There-fore, we aimed to explore abnormalities in the DC of the rTLE and whether such alterations could be applied to the diagnosis of rTLE. Resting-state functional magnetic resonance imaging (fMRI) was used to scan 82 patients with rTLE and 69 healthy controls. The DC and support vector machine (SVM) methods were used for an analysis of the imaging data. Compared to the control group, the rTLE patients exhibited lower DC values in the right hippocam-pus, right superior temporal gyrus, and right caudate. Compared to the control group, the rTLE patients showed higher DC values in the right medial superior frontal gyrus (SFGmed), left dorsolateral superior frontal gyrus (SFGdor), right inferior parietal lobule (IPL), and the left postcentral. The highest diagnostic accuracy of 99.34% (150/151), based on SVM analysis, was demonstrated for the combination of abnormal DC in the right IPL and the left SFGdor, along with a sensitivity of 100% (82/82), and a specificity of 98.55% (68/69) for the differ-entiation of rTLE patients from healthy controls. The study demonstrated abnormal functional connectivity in rTLE patients. Thus, a distinctive DC pattern may serve as an imaging marker for the diagnosis of rTLE patients. (c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.