Circadian rhythm and autonomic dysfunction in presymptomatic and early Huntington's disease
Circadian rhythm and autonomic dysfunction in presymptomatic and early Huntington's disease
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DOI：
10.1016/j.parkreldis.2017.09.013
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发表时间：
2017-11-01
影响因子：
4.1
通讯作者：
Lopez del Val, Javier
中科院分区：
文献类型：
--
作者：
Bellosta Diago, Elena;Perez Perez, Jesus;Lopez del Val, Javier
引言：睡眠和昼夜节律紊乱在神经退行性疾病（如亨廷顿病（HD））患者中很常见。本研究的目的是评估昼夜血压（BP）的变异性，以确定异常昼夜血压和睡眠质量之间的关联HD.Methods患者：横断面，多中心研究38 HD突变携带者（23 premanifest和15早期患者）进行了比较，38个年龄和性别匹配的对照。动态血压监测（ABPM）评估血压。根据夜间血压下降的百分比，受试者被分为杓型（>= 10%）或非杓型（5）（p = 0.016），与对照组相比，白天过度嗜睡（ESS>9）（p = 0.001）。夜间非浸渍与较差的睡眠质量的患者（p = 0.011），但不是在controls.Conclusion：这些结果表明，HD患者目前的血压昼夜节律的早期紊乱，这种改变夜间BP与睡眠质量差。这些发现表明，在这个人群中的潜在作用微妙的下丘脑功能障碍。(C)2017爱思唯尔有限公司版权所有。
Introduction: Sleep and circadian rhythm disturbances are common in patients with neurodegenerative diseases such as Huntington's disease (HD). The aim of this study was to evaluate variability in circadian blood pressure (BP) to determine the association between abnormal circadian BP and sleep quality in patients with HD.Methods: Cross-sectional, multicenter study of 38 HD mutation carriers (23 premanifest and 15 early stage patients) who were compared to 38 age- and sex-matched controls. BP was evaluated by ambulatory blood pressure monitoring (ABPM). Based on the percentage decrease in nocturnal BP, subjects were classified as either dippers (>= 10%) or non-dippers (5) (p = 0.016) with more excessive daytime sleepiness (ESS>9) (p = 0.001) than in the control group. Nocturnal non-dipping was associated with worse sleep quality in patients (p = 0.011) but not in controls.Conclusion: These results show that patients with HD present early disturbances in the circadian rhythm of BP and that this altered nocturnal BP is associated with poor sleep quality. These findings suggest the potential role of subtle hypothalamic dysfunction in this population. (C) 2017 Elsevier Ltd. All rights reserved.