The Role of Interleukin-19 in Contact Hypersensitivity
The Role of Interleukin-19 in Contact Hypersensitivity
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DOI：
10.1248/bpb.b17-00594
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发表时间：
2018-02-01
影响因子：
2
通讯作者：
Azuma, Yasu-Taka
中科院分区：
文献类型：
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作者：
Fujimoto, Yasuyuki;Fujita, Takashi;Azuma, Yasu-Taka
白细胞介素（IL）-19是白细胞介素的IL-10家族的成员，并且是由主要巨噬细胞产生的免疫调节细胞因子。IL-19敲除小鼠的胃肠道组织显示由先天免疫系统和T细胞介导的实验性结肠炎恶化。IL-19与T细胞功能的相互作用和关系越来越受到关注。接触性超敏反应（CHS）是T细胞介导的皮肤炎症。因此，我们询问IL-19是否导致CHS。我们研究了IL-19在1-氟-2，4-二硝基氟苯诱导的CHS中的免疫学作用。IL-19在暴露于半抗原的皮肤中高度表达，并且在IL-19敲除小鼠中耳肿胀增加。IL-19敲除小鼠CHS反应的加剧与IL-17和IL-6水平的增加相关，但在淋巴结T细胞中的干扰素（IFN）γ和IL-4的产生中没有观察到改变。除了对T细胞应答的影响外，IL-19敲除小鼠还增加了炎性细胞因子的产生。这些结果表明IL-19在CHS的诱发阶段抑制半抗原依赖性皮肤炎症。
Interleukin (IL)-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. The gastrointestinal tissues of IL-19 knockout mice show exacerbated experimental colitis mediated by the innate immune system and T cells. There is an increasing focus on the interaction and relationship of IL-19 with the function of T cells. Contact hypersensitivity (CHS) is T cell-mediated cutaneous inflammation. Therefore, we asked whether IL-19 causes CHS. We investigated the immunological role of IL-19 in CHS induced by 1-fluoro-2,4-dinitrofluorobenzene as a hapten. IL-19 was highly expressed in skin exposed to the hapten, and ear swelling was increased in IL-19 knockout mice. The exacerbation of the CHS response in IL-19 knockout mice correlated with increased levels of IL-17 and IL-6, but no alterations were noted in the production of interferon (IFN)gamma and IL-4 in the T cells of the lymph nodes. In addition to the effect on T cell response, IL-19 knockout mice increased production of inflammatory cytokines. These results show that IL-19 suppressed hapten-dependent skin inflammation in the elicitation phase of CHS.