Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques
Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques
复制标题
DOI：
10.1111/j.1530-0277.2008.00730.x
复制
发表时间：
2008-09-01
影响因子：
3.2
通讯作者：
Fox, Howard
中科院分区：
文献类型：
--
作者：
Marcondes, Maria Cecilia G.;Watry, Debbie;Fox, Howard
背景：饮酒是艾滋病毒感染者的一个常见问题，酒精的影响可能会改变免疫反应的效率，可能会加重病情并影响终末器官，例如大脑。然而，由乙醇调节的病毒与宿主相互作用的要素却很少被剖析。 方法：在 SIV 感染之前，对恒河猴的乙醇摄入进行调节，以模仿这种常见的人类行为，并允许在急性时间点、感染的重要方面建立以及病毒可重复地进入宿主细胞时评估病毒与免疫系统相互作用的各个方面。 结果：虽然乙醇对急性血浆病毒载量的影响有限，但它导致循环记忆CD4(+) T细胞减少，并增加表达病毒辅助受体CCR5的单核细胞水平。在器官中，饮酒会影响肝脏以及淋巴和其他非淋巴组织中的免疫细胞，其中 CD4(+) T 细胞主要受到影响。结论：总体而言，饮酒会导致免疫细胞发生变化，从而在 SIV 感染时产生疾病易感环境。
Background: Alcohol consumption is a common problem in HIV-infected individuals, and the effects of alcohol may alter the efficiency of the immune response, potentially aggravating the disease as well as affecting end organs, such as the brain. However, the elements of the virus-host interaction that are modulated by ethanol are poorly dissected.Methods: Ethanol intake was conditioned in rhesus macaques prior to SIV infection, in order to mimic this common human behavior, and allow the evaluation of aspects of the virus-immune system interactions during acute time-points, when important facets of the infection are set up and when virus reproducibly enters the brain.Results: Although ethanol had a limited effect on the acute plasma viral load, it resulted in reduced circulating memory CD4(+) T cells and increased levels of monocytes expressing the viral coreceptor CCR5. In organs, ethanol consumption impacted immune cells in the liver as well as lymphoid and other nonlymphoid tissues, where CD4(+) T cells were predominantly affected.Conclusion: Overall, the consumption of alcohol causes immune cell alterations that can contribute to the generation of a disease susceptible environment upon SIV infection.