Wave propagation in a model of the arterial circulation
Wave propagation in a model of the arterial circulation
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DOI：
10.1016/j.jbiomech.2003.09.007
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发表时间：
2004-04-01
影响因子：
2.4
通讯作者：
Parker, KH
中科院分区：
文献类型：
--
作者：
Wang, JJ;Parker, KH
动脉脉搏波在体大动脉中的传播已经使用特性分析的线性化方法来计算，以跟随由心脏产生的波。该模型包括55个最大动脉的解剖学和生理学数据，调整后的动脉分叉树与前向行波很好地匹配。模型中的外周动脉由阻力元件终止，所述阻力元件被调节以产生平均血流的生理上合理的分布。在该模型中，由左心室收缩产生的压力和速度波传播到其被反射的外周。这些反射波被它们遇到的每个分叉重新反射，并且生成非常复杂的波图案。计算结果显示了体动脉的许多特征，包括脉压随着远离心脏的距离而增加，以及收缩晚期期间从升主动脉到腹主动脉再到腿部动脉的回流幅度的初始降低和随后的大幅增加。然后，该模型被用来研究波的反射或吸收的心脏和机制，导致切迹的影响进行了研究。进行计算与不同的动脉段的完全闭塞，以模型实验中，不同的动脉的闭塞对升主动脉中的压力和流量的影响进行了测量。最后，还研究了周向阻力变化对压力和速度波形的影响。我们得出结论，从这些计算中，波在大动脉中的传播的复杂模式可能是动脉血流动力学的最重要的决定因素。(C)2003 Elsevier Ltd.保留所有权利。
The propagation of the arterial pulse wave in the large systemic arteries has been calculated using a linearised method of characteristics analysis to follow the waves generated by the heart. The model includes anatomical and physiological data for the 55 largest arteries adjusted so that the bifurcating tree of arteries is well matched for forward travelling waves. The peripheral arteries in the model are terminated by resistance elements which are adjusted to produce a physiologically reasonable distribution of mean blood flow. In the model, the pressure and velocity wave generated by the contraction of the left ventricle propagates to the periphery where it is reflected. These reflected waves are re-reflected by each of the bifurcations that they encounter and a very complex pattern of waves is generated. The results of the calculations exhibit many of the features of the systemic arteries, including the increase of the pulse pressure with distance away from the heart as well as the initial decrease and then the large increase in the magnitude of back flow during late systole going from the ascending aorta to the abdominal aorta to the arteries of the leg. The model is then used to study the effects of the reflection or absorption of waves by the heart and the mechanisms leading to the incisura are investigated. Calculations are carried out with the total occlusion of different arterial segments in order to model experiments in which the effects of the occlusion of different arteries on pressure and flow in the ascending aorta were measured. Finally, the effects of changes in peripheral resistance on pressure and velocity waveforms are also studied. We conclude from these calculations that the complex pattern of wave propagation in the large arteries may be the most important determinant of arterial haemodynamics. (C) 2003 Elsevier Ltd. All rights reserved.