Light-controlled oxygen production and collection for sustainable photodynamic therapy in tumor hypoxia
Light-controlled oxygen production and collection for sustainable photodynamic therapy in tumor hypoxia
复制标题
光控氧气的产生和收集，用于肿瘤缺氧的可持续光动力治疗。
DOI：
10.1016/j.biomaterials.2020.120621
复制
发表时间：
2021-02-01
期刊：
影响因子：
14
通讯作者：
Wu, Jinhui
中科院分区：
文献类型：
--
作者：
Wang, Haoran;Guo, Yunfei;Wu, Jinhui
缺氧存在于大多数恶性肿瘤中，并且通常有助于治疗抵抗，特别是对于有氧治疗，例如光动力治疗（PDT）和放射治疗。在这里，我们开发了一种新型的光控可持续PDT，其中光被用来帮助光合微生物（小球藻）产生氧气，全氟化碳被用来丰富周围的光敏剂持续供氧的氧气。在光停止后，小球藻进一步充当佐剂以促进树突状细胞（DC）活化，从而促进抗肿瘤免疫应答。我们发现，可持续的PDT可以持续地为光敏剂提供氧气，避免PDT引起的局部缺氧。更重要的是，持续PDT还促进了DC的活化，增强了抗肿瘤免疫效应。因此，这种新的策略提供了一种有效而简单的方法来改善肿瘤缺氧和常氧的PDT，增强抗肿瘤免疫可能是治疗晚期癌症患者的新的抗耐药策略。
Hypoxia exists in most malignant tumors and often contributes to therapy resistance, especially for aerobic treatments such as photodynamic therapy (PDT) and radiotherapy. Here, we developed a novel light-controlled sustainable PDT in which light was used to help photosynthetic microorganisms (Chlorella) produce oxygen, and perfluorocarbon was used to enrich oxygen around the photosensitizer for sustained oxygen supply. After light stops, Chlorella further acts as an adjuvant to promote dendritic cell (DC) activation, promoting the antitumor immune response. We showed that sustainable PDT could continuously provide oxygen for photosensitizers and avoid PDT-induced local hypoxia. More importantly, sustainable PDT also promoted the activation of DCs and amplified the antitumor immune effects. Therefore, this novel strategy provides an effective but simple method for improving PDT in both tumor hypoxia and normoxia, and enhancing the antitumor immunity may be a new anti-resistance strategy for treating patients with advanced-stage cancer.